山口 晃史

氏名 やまぐち こうし
山口 晃史
Yamaguchi Koushi
所属・役職 女性総合診療センター 女性内科　診療部長
周産期病態研究部 母体管理室　室長（併任）
妊娠と薬情報センター　センター長
経歴 1985-1987年　 順天堂大学内科研修医
1987年　　　　順天堂大学内科（現・膠原病内科）入局
1988年　 順天堂大学内科（現・膠原病内科）助手
1989-1991年 国立予防衛生研究所(現・国立感染症研究所)エイズ予防財団ﾘｻ-ﾁﾚｼﾞﾃﾞﾝﾄ
1991-1995年　 ハーバード大学医学部付属病院 留学
1996-2011年 国立感染症研究所エイズ第1グループ協力研究員
1997年　 昭和大学医学部細菌学教室助手
1998年　 昭和大学医学部細菌学教室講師
2002年 国立成育医療センター周産期診療部母性内科医員
2009年 国立成育医療研究センター周産期診療部母性内科医長
2011年-現在 国立成育医療研究センター周産期病態研究部母体管理室長
2013年-現在 国立成育医療研究センター周産期・母性診療センター診療部長
専門分野 合併症妊娠
免疫疾患
感染症
膠原病
資格 医学博士（順天堂大学）
日本内科学会総合内科専門医
アメリカ内科学会認定内科医
日本感染症学会認定感染症専門医
日本感染症学会認定感染症指導医
ICD(Infection Control Doctor)
日本医師会認定産業医
所属学会 日本内科学会
アメリカ内科学会
日本感染症学会
日本リウマチ学会
日本周産期・新生児医学会
当院での業績
  1. Yamaguchi K, Yamamoto Y, Murashima A: Clarithromycin reduces prednisolone requirements for treatment of intractable Takayasu arteritis. Clinical and Experimental Rheumatology. 2004; 22: S-102.
  2. Yamaguchi K, Yamamoto A, Hisano M, Natori M, Murashima A: Herpes simplex virus 2 (HSV-2)-associated hemophagocytic lymphohistiocytosis in a pregnant patient. Obstetrics and Gynecology 2005; 105: 1241-1244.
  3. HisanoM, Sakata M, Watanabe N, Kitagawa M, Murashima A, Yamaguchi K: An acromegalic woman first diagnosed in pregnancy. Archives of Gynecology and Obstetrics 2006; 274; 171-173.
  4. Yamaguchi K, Hisano M, Sakata M, Minatogawa Y, Suzuki T, Ozawa N, Kitagawa M, Murashima A: Periodical platelet pheresis for a high risk essential thrombocythemia patient in pregnancy. Journal of Clinical Apheresis 2006; 21; 256-259.
  5. Yamaguchi K, Sugiyama T, Takizawa M, Honda M, Yamamoto N and Natori M: Viability of infectious viral particles of HIV and BMCs in breast milk. Journal of Clinical Virology 2007; 39: 222-225.
  6. Hisano M, Sugawara K, Tatsuzawa O, Kitagawa M, Murashima A, Yamaguchi K: Burkholderia cepacia-associated hemophagocytic syndrome and septic pulmonary embolism in a woman with chronic granulomatous disease. Journal of Medical Microbiology 2007; 56; 702-705.
  7. Yamaguchi K, Kato S, Kondo Y, Sugiyama T, Iwata M, Ageyama N, Koyanagi Y, Yamamoto N and Honda M: A novel CD4-conjugated ultraviolet light-activated photocatalyst inactivates HIV-1 and SIV efficiently. Journal of Medical Virology 2008; 80: 1322-1331.
  8. Yamaguchi K, Hisano M, Isojima S, Irie S, Arata N, Watanabe N, Kubo T, Kato T, Murashima A. Relationship of Th1/Th2 cell balance with the immune response to influenza vaccine during pregnancy. J Med Virol. 2009; 81: 1923-1928.
  9. Murashima A, Watanabe N, Ozawa N, Saito H, Yamaguchi K: Etanercept during pregnancy and lactation in a patient with rheumatoid arthritis: Drug levels in maternal serum, cord blood, breast milk and the infant's serum. Annals of the Rheumatic Diseases 2009; 68: 1793-1794.
  10. Hisano M, Suzuki R, Sago H, Murashima A, Yamaguchi K: Vitamin B6 deficiency and anemia in pregnancy. European Journal of Clinical Nutrition. 2010; 64: 221-223.
  11. Isojima S, Hisano M, Suzuki T, Sago H, Murashima A and Yamaguchi K: Early plasmapheresis followed by high-dose -globulin treatment saved a severely Rho-incompatible pregnancy. Journal of Clinical Apheresis 2011; 26: 216-8.
  12. Hisano M, Kobayashi S, Arata N, Murashima A and Yamaguchi K: Successful completion of pregnancy in a woman with chronic granulomatous disease. Obstetric Medicine 2011; 4: 174-176.
  13. Horiya M, Hisano M, Iwasaki Y, Hanaoka M, Watanabe N, Ito Y, Kojima J, Sago H, Murashima A, Kato T, and Yamaguchi K. Efficacy of double vaccination with the 2009 pandemic influenza A (H1N1) vaccine during pregnancy. Obstetrics and Gynecology 2011; 118: 887-894.
  14. Hisano M, Yamaguchi K. Usefulness of influenza vaccination during pregnancy to mothers and young infants. Expert Rev Vaccines. 2012; 11: 903-5.
  15. Kanda E, Yamaguchi K, Hanaoka M, Matsui H, Sago H, Kubo T. Low titers of measles antibodies in Japanese pregnant women: A single-center study. J Obstet Gynaecol Res. 2013; 39:500-3.
  16. Hanaoka M, Hisano M, Watanabe N, Sugawara K, Kambe Y, Kanda E, Sago H, Kato T and Yamaguchi K. Changes in the prevalence of the measles, rubella, varicella-zoster, and mumps virus antibody titers in Japanese pregnant women. Vaccine. 2013; 31: 2343-2347.
  17. Takahashi H, Hisano M, Sago H, Murashima A, and Yamaguchi K. Hypoproteinemia in the second trimester among patients with preeclampsia prior to the onset of clinical symptoms. Hypertens pregnancy. 2014; 33:55-60.
  18. Watanabe N, Yamaguchi K, Motomura K, Hisano M, Sago H and Murashima A. Combination therapy with anticoagulants, corticosteroids and intravenous immunoglobulin for women with severe obstetric antiphospholipid syndrome. Clinical Experimental Rheumatology. 2014; 2014; 32: 299-300.
  19. Sugiyama R, Nakagawa K, Hisano M, Mitui M, Yamaguchi K. The ovarian stimulation method can cause oxidative stress in the follicular fluid. Hum. Reprod 2014; 29 supplement 1: i309-310 (P-463).
  20. Matsuki Y, Atsumi T, Yamaguchi K, Hisano M, Arata N, Oku K, Watanabe N, Sago H, Takasaki Y, Murashima A. Clinical features and pregnancy outcome in antiphospholipid syndrome patients with history of severe pregnancy complications. Mod Rheumatol. 2015;25:215-8.
  21. Kamei K, Yamaguchi K, Sato M, Ogura M, Ito S, Okada T, Wada S, Sago H. Successful treatment of severe rhesus D-incompatible pregnancy with repeated double-filtration plasmapheresis. J Clin Apher. 2015；30：305-7.
  22. Nakagawa K, Kwak-Kim J, Ota K, Kuroda K, Hisano M, Sugiyama R, Yamaguchi K. Immunosuppression with Tacrolimus Improved Reproductive Outcome of Women with Repeated Implantation Failure and Elevated Peripheral Blood Th1/Th2 Cell Ratios. Am J Reprod Immunol. 2015; 73: 353-61.
  23. Hisano M, Tsukada N, Sago H and Yamaguchi K. Successful prevention of exacerbation of thrombocytopenia in a pregnant patient with idiopathic thrombocytopenic purpura by anticoagulation treatment. BMC Pregnancy Childbirth. 2015; 15:482.
  24. Takeda S, Hisano M, Komano J, Sago H and Yamaguchi K. Influenza vaccination during pregnancy and its usefulness to mothers and their young infants. J Infect Chemother. 2015 ;21: 238-246.
  25. Hanaoka M, Hisano M, Hama I, Tsukamoto K, Ito R, Ito Y, Sago H, Matsui A, Yamaguchi K. Hepatitis B virus surface antibody titers in babies administered hepatitis B immune globulin both intravenously and intramuscularly after birth. J Matern Fetal Neonatal Med. 2015;28:1-4.
  26. Nakagawa K, Hisano M, Sugiyama R, Yamaguchi K. Measurement of oxidative stress in the follicular fluid of infertility patients with an endometrioma. Arch Gynecol Obstet. 2016; 293:197-202.
  27. Hisano M, Kato T, Inoue E, Sago H, Yamaguchi K. Evaluation of measles-rubella vaccination for mothers in early puerperal phase. Vaccine. 2016; 34: 1208-14.
  28. Sasaki A, Motomura K, Suyama F, Nagasawa J, Hisano M, Ito R, Miyazaki O, Nakazawa A, Ito Y, Kasahara M, Asai A, Matsumoto K, Sago H, Yamaguchi K. Fetal magnetic resonance imaging detection of liver iron deposition in neonatal hemochromatosis during prenatal therapy. J Pediatr Gastroenterol Nutr. 2016;63:e121.
  29. Aiko Sasaki, Kumiko Kuroda, Michi Hisano, Nobuaki Ozawa, Haruhiko Sago & Koushi Yamaguchi. Successful treatment for a recurrent pregnancy loss woman with high Th1/Th2 ratio using medium-dose corticosteroids.J Obstet Gynaecol. 2017; 37:685-687.
  30. Nakagawa K, Kwak-Kim J, Kuroda K, Sugiyama R, Yamaguchi K.Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures.Am J Reprod Immunol. 2017;doi: 10.1111/aji.12682. Epub 2017 May 3.
  31. Ozawa N, Yamaguchi K, Shibata M, Sugibayashi R, Yagi H, Sago H, Matsuoka K.Chronic histiocytic intervillositis in three consecutive pregnancies in a single patient: Differing clinical results and pathology according to treatment used.J Obstet Gynaecol Res. 2017;43:1504-1508.
  32. Nakagawa K, Kuroda K, Sugiyama R, Yamaguchi K.After 12 consecutive miscarriages, a patient received immunosuppressive treatment and delivered an intact baby.Reprod Med Biol. 2017;21;16:297-301.
  33. Hanaoka M, Hisano M, Tsukamoto K, Ito R, Ito Y, Sago H, Matsui A and Yamaguchi K. Infants born to HBV genotype A-carrier mothers have begun to appear in Japan. Journal of Clinical Obstetrics, Gynecology & Infertility. 2017; vol1: Article 1021 (on line).
  34. Okada N, Sasaki A, Saito J, Mitani Y, Yachie A, Takahashi H, Matsubara S, Tenkumo C, Tanaka H, Hata T, Motomura K, Nagasawa J, Wada Y, Sako M, Yamaguchi K, Matsumoto K, Nakamura H, Sago H, Mizuta K. The Japanese experience and pharmacokinetics of antenatal maternal high-dose immunoglobulin treatment as a prophylaxis for neonatal hemochromatosis in siblings. J Matern Fetal Neonatal Med. 2018 Jul 22:1-7. doi: 10.1080/14767058.2018.1487940. [Epub ahead of print]
  35. Yamaguchi K. Tacrolimus treatment for infertility related to maternal-fetal immune interactions. Am J Reprod Immunol. 2019 Jan 28:e13097. doi: 10.1111/aji.13097. [Epub ahead of print. PMID: 30689243
  36. Nakagawa K, Funaki S, Hisano M, Sugiyama R, Yamaguchi K. Tacrolimus treatment saved a Rho-incompatible pregnancy. J Matern Fetal Neonatal Med. 2019 accepted. doi: 10.1080/14767058.2019.1587406 [Epub ahead of print]
  37. Cuningham W, Geard N, Fielding JE, Braat S, Madhi SA, Nunes MC, Christian LM, Lin S-Y, Lee CN, Yamaguchi K, Bisgaard H, Chawes B, Chao A-S, Blanchard-Rohner G, Elizabeth P. Schlaudecker, Fisher BM, McVernon J, Moss R. Optimal Timing of Influenza Vaccine during Pregnancy: a Systematic Review and Meta-Analysis. Influenza and Other Respiratory Viruses 2019 accepted. doi: 10.1111/irv.12649
  38. Nakagawa K, Kwak-Kim J, Hisano M, Kasahara Y, Kuroda K, Sugiyama R, Yamaguchi K. Obstetric and perinatal outcome of the women with repeated implantation failures or recurrent pregnancy losses who received pre- and post- conception tacrolimus treatment. Am J Reprod Immunol. 2019 May 13:e13142. doi: 10.1111/aji.13142.
  39. Hisano M, Mitsui M, Sago H, Yamaguchi K. Thromboprophylaxis with antithrombin gamma and unfractionated heparin for a pregnant woman complicated by hereditary antithrombin deficiency. Int J Gynaecol Obstet. 2019 Oct 12. doi: 10.1002/ijgo.12996. [Epub ahead of print]