Medical Research Center for Japan Environment and Children's Study (JECS)

The Japan Environment and Children's Study (JECS), one of the largest birth cohorts to date enrolling more than 100,000 mother-child pairs, has been conducted nationwide since 2011. Our mission is to support the planning, implementation, and management of the JECS from a medical perspective.

Our missions

The JECS study?also known as the Ecochil survey?aims to investigate the most important aspects of child development by focusing on the environments in which children are brought up. After initial planning by the Ministry of the Environment, recruitment for the survey commenced in 2011, and focused on particular birth cohorts.

The study recruited 100,000 pregnant women over the course of three years in 15 unit centers based at universities and their affiliated hospitals all over Japan. We are now undertaking the most important part of the survey by following-up participants, whereby we track the health of participating children from the intrauterine period up until the age of 13 years.

The National Institute for Environmental Studies (Core Center) plays a central role in administering the survey and is supported by the Medical Support Center, which provides medical expertise in the investigation of the health statuses of mothers and their children.

The survey is being carried out in collaboration with the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labour and Welfare. Moreover, the project supports co-operation with international agencies and the use of data from overseas research institutes.

From 2022, a large scale genetic study of JECS, by genotyping 85,000 children, will begin to improve child health and development typically for those who belong to a genetically vulnerable group to specific environmental contaminants.

Members

Bibliography

2020

1. Sasaki, H, Arata, N, Tomotaki, A, Yamamoto-Hanada, K, Mezawa, H, Konishi, M, Ishitsuka, K, Saito-Abe, M, Sato, M, Nishizato, M, Saito, H & Ohya, Y. Time Course of Metabolic Status in Pregnant Women: the Japan Environment and Children's Study (JECS). Journal of Diabetes Investigation. First published:21 February (2020)
2. Ishitsuka K*, Yamamoto-Hanada K, Mezawa H, Saito-Abe M, Konishi M, Ohya Y, the Japan Environment and Children's Study Group. Determinants of alcohol consumption in women before and after awareness of conception. Maternal and Child Health Journal. 2020 Feb;24(2):165-176.
3. Ishitsuka K, Sasaki S, Yamamoto-Hanada K, Mezawa H, Konishi M, Ohya Y*, the Japan Environment and Children's Study Group. Changes in dietary intake in pregnant women from periconception to pregnancy in the Japan Environment and Children's Study, a nationwide Japanese birth cohort. Maternal and Child Health Journal. 2020 Mar;24(3):389-400.
4. Yamamoto-Hanada K, Kawakami E, Saito-Abe M, Sato M, Mitsubuchi H, Oda M, Katoh T, Sanefuji M, Ohga S, Kuwajima M, Mise N, Ikegami A, Kayama F, Senju A, Shimono M, Kusuhara K, Yamazaki S, Nakayama SF, Matsumoto K, Saito H, Ohya Y. Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study. Cytokine. 2020 Mar 6;130:155051.
5. Yamamoto-Hanada K, Borres MP, Aberg MK, Yang L, Fukuie T, Narita M, Saito H, Ohya Y. IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo. World Allergy Organ J. 2020 Feb 25;13(2):100105
6. Yamamoto-Hanada K, Takayama IJ, Futamura M, Saito-Abe M, Ohya Y. Prenatal visits for allergy prevention. Ann Allergy Asthma Immunol. 2020 Feb;124(2):198-200.
7. Saito-Abe M, Yamamoto-Hanada K, Nakayama SF, Hashimoto Y, Natsume O, Fukami M, Hasegawa T, Ohya Y. Reference values for salivary cortisol in heathy young infants by LC-MS/MS. Pediatr Int. 2020 Jan 24.
8. Ishitsuka K*, Yamamoto-Hanada K, Yang L, Mezawa H, Konishi M, Saito-Abe M, Sasaki H, Nishizato M, Sato M, Koeda T, Ohya Y, Japan Environment Children's Study Group. Association between Blood Lead Exposure and Mental Health in Pregnant Women: Results From the Japan Environment and Children's Study. Neurotoxicology. 2020 Jun 8;79:191-199.
9. Irahara M, Yamamoto-Hanada K, Yang L, Saito-Abe M, Sato M, Inuzuka Y, Toyokuni K, Nishimura K, Ishikawa F, Miyaji Y, Fukuie T, Narita M, Ohya Y. Impact of swimming school attendance in 3-year-old children with wheeze and rhinitis at age 5 years: A prospective birth cohort study in Tokyo. PLoS One. 2020 Jun 9;15(6):e0234161.
10. Taniguchi Y, Yamazaki S, Michikawa T, Nakayama SF, Sekiyama M, Nitta H, Mezawa H, Saito-Abe M, Oda M, Mitsubuchi H, Sanefuji M, Ohga S, Mise N, Ikegami A, Shimono M, Suga R. (2020) Associations of dog and cat ownership with wheezing and asthma in children: Pilot study of the Japan Environment and children's study. PLOS ONE 15(5): e0232604.
11. Sato M, Yamamoto-Hanada K, Tada H, Irahara M, Saito-Abe M, Matsumoto K, Pak K, Kido H, Ohya Y. Diagnostic performance of IgE avidity for hen's egg allergy in young infants. J Allergy Clin Immunol Pract. 2020 Apr 5
12. Katoh N, Ohya Y, Ikeda M, Ebihara T, Katayama I, Saeki H, Shimojo N, Tanaka A,Nakahara T, Nagao M, Hide M, Fujita Y, Fujisawa T, Futamura M, Masuda K, Murota H, Yamamoto-Hanada K; Committee for Clinical Practice Guidelines for the Management of Atopic Dermatitis 2018, Japanasese Society of Allergology, Japanese Dermatology Association. Japanese guidelines for atopic dermatitis 2020. Allergol Int. 2020 Apr 4. pii: S1323-8930(20)30018-6.
13. Yamamoto-Hanada K, Kawakami E, Saito-Abe M, Sato M, Mitsubuchi H, Oda M, Katoh T, Sanefuji M, Ohga S, Kuwajima M, Mise N, Ikegami A, Kayama F, Senju A, Shimono M, Kusuhara K, Yamazaki S, Nakayama SF, Matsumoto K, Saito H, Ohya Y. Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study. Cytokine. 2020 Mar 6;130:155051
14. Yamamoto-Hanada K, Pak K, Saito-Abe M, Yang L, Sato M, Mezawa H, Sasaki H, Nishizato M, Konishi M, Ishitsuka K, Matsumoto K, Saito H, Ohya Y; Japan Environment and Children's Study (JECS) Group. Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan. Environ Health Prev Med. 2020 Jul 7;25(1):27.
15. Inagaki S, Nakamura T, Hamasaki Y, Yamamoto-Hanada K, Fukuie T, Narita M, Shimosawa T, Murata T, Ohya Y. Prostaglandin D2 metabolite is not a useful clinical indicator for assessing atopic dermatitis. Clin Exp Dermatol. 2020 Jul 23.
16. Irahara M, Nomura I, Takeuchi I, Yamamoto-Hanada K, Shimizu H, Fukuie T, Yoshioka T, Arai K, Ohya Y. Pediatric patient with eosinophilic esophagitis and pollen-food allergy syndrome. Asia Pac Allergy. 2020 Jul 13;10(3):e28.
17. Iio M, Miyaji Y, Yamamoto-Hanada K, Narita M, Nagata M, Ohya Y. Beneficial Features of a mHealth Asthma App for Children and Caregivers: Qualitative Study. JMIR Mhealth Uhealth. 2020 Aug 24;8(8):e18506.
18. Ishitsuka K, Yamamoto-Hanada K, Yang L, Mezawa H, Konishi M, Saito-Abe M, Sasaki H, Nishizato M, Miori Sato, Koeda T, Ohya Y, Japan Environment Children's Study Group. Association between Blood Lead Exposure and Mental Health in Pregnant Women: Results From the Japan Environment and Children's Study. Neurotoxicology. 2020 Jun 8;79:191-199.
19. Hashimoto, R., Suto, M., Tsuji, M., Sasaki, H., Takehara, K., Ishiguro, A., & Kubota, M. (2020). Use of antipyretics for preventing febrile seizure recurrence in children: a systematic review and meta-analysis. European Journal of Pediatrics, 1-11.
20. Tachimoto H, Imanari E, Mezawa H, Okuyama M, Urashima T, Hirano D, Gocho N, Urashima M. Effect of Avoiding Cow's Milk Formula at Birth on Prevention of Asthma or Recurrent Wheeze Among Young Children: Extended Follow-up From the ABC Randomized Clinical Trial. JAMA Netw Open. 2020;3(10):e2018534. doi:10.1001/jamanetworkopen.2020.18534
21. Funaki S, Umehara N, Mezawa H, Kurakazu M, Matsushima S, Arata N, Okamoto A, Sago H. Ultrasonographic assessment of fetal thyroid in Japan: thyroid circumference and distal femoral and proximal tibial ossification. J Med Ultrasonics 47, 603?608 (2020). https://doi.org/10.1007/s10396-020-01043-5
22. Mayako Saito-Abe, Kiwako Yamamoto-Hanada, Kyongsun Pak, Miori Sato, Makoto Irahara, Hidetoshi Mezawa, Hatoko Sasaki, Minaho Nishizato, Kazue Ishitsuka, Mizuho Konishi, Limin Yang, Yukihiro Ohya, Kohta Suzuki. Association of maternal history of allergic features with preterm pregnancy outcomes in the Japan Environment and Children's Study. Int Arch Allergy Immunol.
23. Ishitsuka K, Yamawaki K, Horikawa M, Nakadate H, Nagai A, Ishiguro A. Clinical Prognostic Factors in Pediatric Patients with Orthostatic Intolerance. Glob Pediatr Health. 2020 Nov16
24. Yamamoto-Hanada K, Pak K, Saito-Abe M, Yang L, Sato M, Irahara M, Mezwa H, Sasaki H, Nishizato M, Ishitsuka K, and Ohya Y. Allergy and immunology in young children of Japan: The JECS cohort. World Allergy Organization Journal 2020; 13.
25. Yang L, Yamamoto-Hanada K, Ishitsuka K, Ayabe T, Mezawa H, Konishi M, Shoda T, Sago H, Saito H, Ohya Y; Japan Environment and Children's Study Group. Medical and surgical complications in pregnancy and obstetric labour complications in the Japan Environment and Children's Study (JECS) cohort: a birth cohort study. J Obstet Gynaecol. 2020 Oct;40(7):918-924.
26. Suzuki H, Tsutsumi Y, Morita H, Motomura K, Umehara N, Sago H, Ito Y, Arai K, Yoshioka T, Ohya Y, Saito H, Matsumoto K, Nomura I. Cord blood eosinophilia precedes neonatal onset of food-protein-induced enterocolitis syndrome (FPIES). Allergol Int. 2020 Nov 16:S1323-8930(20)30142-8.

2019

1. Tsuji M, Koriyama C, Ishihara Y, Yamamoto M, Yamamoto-Hanada K, Kanatani K,Bamai YA, Onishi K, Senju A, Araki S, Shibata E, Morokuma S, Sanefuji M, Kitazawa H, Saito M, Umezawa M, Onoda A, Kusuhara K, Tanaka R, Kawamoto T; Japan Environment & Children's Study Group. Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study. J Epidemiol. 2019 Jan 12.
2. Mitsui-Iwama M, Yamamoto-Hanada K, Fukutomi Y, Hirota R, Muto G, Nakamura T,Yoshikawa T, Nakamura H, Mikami M, Morioka I, Ohya Y. Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study. Asia Pac Allergy. 2019 Jan 21;9(1):e5.
3. Nagata C, Yang L, Yamamoto-Hanada K, Mezawa H, Ayabe T, Ishizuka K, Konishi M,Ohya Y, Saito H, Sago H; Japan Environment & Children's Study Group. Complications and adverse outcomes in pregnancy and childbirth among women who conceived by assisted reproductive technologies: a nationwide birth cohort study of Japan environment and children's study. BMC Pregnancy Childbirth. 2019 Feb 20;19(1):77.
4. Saito-Abe M, Futamura M, Yamamoto-Hanada K, Yang L, Suzuki K, Ohya Y. Topical corticosteroid phobia among caretakers of children with atopic dermatitis: Across-sectional study using TOPICOP in Japan. Pediatr Dermatol. 2019 Mar 18.
5. Irahara M, Shinahara W, Sugimoto M, Ogawa Y, Shitsukawa K, Kubota K, Yang L,Ohya Y, Saito H, Kagami S, Arisawa K, Kido H. Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy. Immun Inflamm Dis. 2019 Mar 11.
6. Katsunuma T, Fujisawa T, Maekawa T, Akashi K, Ohya Y, Adachi Y, Hashimoto K,Mizuno M, Imai T, Oba MS, Sako M, Ohashi Y, Nakamura H. Low-dose l-isoproterenol versus salbutamol in hospitalized pediatric patients with severe acute exacerbation of asthma: A double-blind, randomized controlled trial. Allergol Int. 2019 Mar 5.
7. Kitazawa H, Yamamoto-Hanada K, Saito-Abe M, Ayabe T, Mezawa H, Ishitsuka K, Konishi M, Nakayama SF,Michikawa T, Senju A, Tsuji M, Kusuhara K, Sanefuji M, Ohga S, Oda M, Mitsubuchi H, Katoh T, Ikegami A, Mise N, Matsumoto K, Saito H, Ohya Y. Egg antigen was more abundant than mite antigen in children's bedding: Findings of the pilot study of the Japan Environment and Children's Study (JECS). Allergology International 2019. In press
8. Okuyama M, Mezawa H, Kawai T, Urashima M.Elevated Soluble PD-L1 in Pregnant Women's Serum Suppresses the Immune Reaction.Front Immunol. 2019 Feb 18;10:86. doi: 10.3389/fimmu.2019.00086. eCollection 2019.
9. Mizuho Konishi, Junko Kamoshida, Hisako Ogasawara, Mieko Takahashi, Yukihiro Ohya.Tentative development of a psychoeducational program for alleviating psychological burden Of mothers of young children with milk allergy Journal of Health Psychology Research. 2019 vol.31, pp183-193.
10. Emiko Noguchi, Ryota Koseki, Wataru Morii, Moena Ishikawa, Limin Yang, Kiwako Yamamoto-Hanada, Masami Narita, Hirohisa Saito, and Yukihiro Ohya. Effect of filaggrin loss-of-function mutations on atopic dermatitis in young age: a longitudinal birth cohort study.Journal of Human Genetics.
11. Irahara M, Shinahara W, Sugimoto M, Ogawa Y, Shitsukawa K, Kubota K, Ohya Y, Saito H, Kagami S, Kido H. Ovomucoid-specific IgG4 level in cord blood associates negatively with later sensitization. Pediatr Allergy Immunol. 2019 Aug 23.
12. Sasaki A, Sugimoto M, Tokaji N, Irahara M, Okamoto K, Uehara H, Kagami S. Efficacy of an elimination diet in a patient with eosinophilic gastroenteritis : a pediatric case with multiple food allergies. J Med Invest. 2019;66(1.2):201-204.
13. Mezawa, H, Aoki, S, Nakayama, S. F, Nitta, H, Ikeda, N, Kato, K, Tamai, S, Takekoh, M, Sanefuji, M, Ohga, S , Oda, M, Mitsubuchi, H, Senju, A, Kusuhara, , Kuwajima, M, Koeda, T, Ohya, Y. and Hashimoto, K. (2019), Psychometric profiles of the Ages and Stages Questionnaires, Japanese translation. Pediatrics International. Accepted Author Manuscript.
14. Sato S, Moverare R, Ohya Y, Ito K, Nagao M, Borres MP, Ebisawa M. Ana o 3-specific IgE is a predictive marker for cashew oral food challenge failure. JAllergy Clin Immunol Pract. 2019 May 17.
15. Katsunuma T, Fujisawa T, Maekawa T, Akashi K, Ohya Y, Adachi Y, Hashimoto K,Mizuno M, Imai T, Oba MS, Sako M, Ohashi Y, Nakamura H. Low-dose l-isoproterenol versus salbutamol in hospitalized pediatric patients with severe acute exacerbation of asthma: A double-blind, randomized controlled trial. Allergol Int. 2019 Mar 5
16. Noyuri Y, Lopes KS, Shoda T, Ishitsuka K, Kobayashi T, Ota E, Mori R. TNF-α blockers for the treatment of Kawasaki disease in children. Cochrane Database Syst Rev. 2019 Aug 16;8:CD012448.
17. Urashima M, Mezawa H, Okuyama M, Urashima T, Hirano D, Gocho N, Tachimoto H. Primary Prevention of Cow's Milk Sensitization and Food Allergy by Avoiding Supplementation With Cow's Milk Formula at Birth: A Randomized Clinical Trial. JAMA Pediatr. 2019;173(12):1137-1145.
18. Limin Yang; Kiwako Yamamoto-Hanada; Kazue Ishitsuka; Tadayuki Ayabe; Hidetoshi Mezawa; Mizuho Konishi; Tetsuo Shoda; Haruhiko Sago; Hirohisa Saito; Yukihiro Ohya; and The Japan Environment and Children's Study Group. Medical and surgical complications in pregnancy and obstetric labour complications in the Japan Environment and Children's Study (JECS) cohort: a birth cohort study. Journal of Obstetrics and Gynaecology. 28 Nov 2019;1-7 .
19. Kazue Ishitsuka*, Kiwako Yamamoto-Hanada, Tadayuki Ayabe, Hidetoshi Mezawa, Mizuho Konishi, Mayako Saito-Abe, Yukihiro Ohya. Risky health behaviors of teenage mothers and infant outcomes in the Japan environment and children's study: a nationwide cohort study. Journal of Pediatric and Adolescent Gynecology 32(2):146-152,2019.
20. Yamawaki K*, Ishitsuka K, Suyama S, Suzumura S, Yamashita H, Kanba S. Clinical characteristics of boys with comorbid ASD and ADHD. Pediatrics International 2019.
21. Katoh N, Ohya Y, Ikeda M, Ebihara T, Katayama I, Saeki H, Shimojo N, Tanaka A, Nakahara T, Nagao M, Hide M, Fujita Y, Fujisawa T, Futamura M, Masuda K, Murota H, Yamamoto-Hanada K. Clinical practice guidelines for the management of atopic dermatitis 2018. J Dermatol. 2019 Oct 9.
22. Irahara M, Shinahara W, Sugimoto M, Ogawa Y, Shitsukawa K, Kubota K, Ohya Y, Saito H, Kagami S, Kido H. Ovomucoid-specific IgG4 level in cord blood associates negatively with later sensitization. Pediatr Allergy Immunol. 2019 Dec;30(8):857-860.
23. Sato M, Yamamoto-Hanada K, Yang L, Irahara M, Ishikawa F, Motoko Iwama-Mitsui, Mayako Saito-Abe, Miyaji Y, Inagaki S, Fukuie T, Nomura I, Narita M, Kohta Suzuki Kand Y and Ohya Y. Complementary and alternative medicine and atopic dermatitis in children
24. Yamamoto-Hanada K, Takayama IJ, Futamura M, Saito-Abe M, Ohya Y.Implementation science into the public - pregnant women need to prenatal visit for allergy prevention? Ann Allergy Asthma Immunol.2019 in press
25. Miyaji Y, Yang L, Yamamoto-Hanada K, Narita M, Saito H, Ohya Y. Earlier aggressive treatment to shorten the duration of eczema in infants resulted in fewer food allergies at 2 years of age. J Allergy Clin Immunol Pract. 2019 Dec 7.

2018

1. Yamamoto-Hanada K, Ishitsuka K, Pak K, Saito M, Ayabe T, Mezawa H, Konishi M, Yang L, Matsumoto K, Saito H, Ohya Y; Japan Environment and Children's Study (JECS) Group: Allergy and mental health among pregnant women in the Japan Environment and Children's Study. J Allergy Clin Immunol Pract. 2018 Jan 20. pii:S2213-2198(17)31024-3.
2. Natsume O, Ohya Y. Recent advancement to prevent the development of allergy and allergic diseases and therapeutic strategy in the perspective of barrier dysfunction: Allergol Int. 2018 Jan;67(1):24-31.
3. Ayabe T, Yamamoto-Hanada K, Mezawa H, Konishi M, Ishitsuka K, Saito M, Fukami M, Michikawa T, Yamazaki S, Senju A, Kusuhara K, Kawamoto T, Sanefuji M, Kato K, Oda M, Mitsubuchi H, Katoh T, Monden Y, Mise N, Kayama F, Saito H, Ohya Y: Regional differences in infant 25-Hydroxyvitamin D: Pilot study of the Japan Environment and Children's Study. Pediatr Int. 2018 Jan;60(1):30-34.
4. Mito A, Arata N, Qiu D, Sakamoto N, Murashima A, Ichihara A, Matsuoka R, Sekizawa A, Ohya Y, Kitagawa M: Hypertensive disorders of pregnancy: a strong risk factor for subsequent hypertension 5 years after delivery. Hypertens Res. 2018 Feb;41(2):141-146.
5. Nagao M, Inagaki S, Kawano T, Azuma Y, Nomura N, Noguchi Y, Ohta S, Kawaguchi A, Odajima H, Ohya Y, Fujisawa T, Izuhara K: SCCA2 is a reliable biomarker for evaluating pediatric atopic dermatitis. J Allergy Clin Immunol. 2018 Feb 5.
6. Aoki S, Hashimoto K, Mezawa H, Hatakenaka Y, Yasumitsu-Lovell K, Suganuma N, Ohya Y, Wilson P, Fernell E, Kamio Y, Gillberg C. Development of a new screening tool for neuromotor development in hildren aged two - the neuromotor 5?min exam 2-year-old version (N5E2). Brain Dev. 2018;40: 445-451.
7. Matsumoto K, Mori R, Miyazaki C, Ohya Y, Saito H. Are both early egg introduction and eczema treatment necessary for primary prevention of egg allergy? : J Allergy Clin Immunol. 2018 Mar 6.
8. Yang L, Narita M, Yamamoto-Hanada K, Sakamoto N, Saito H, Ohya Y. Phenotypes of Childhood Wheeze in Japanese children: A Group-Based Trajectory Analysis. Pediatr Allergy Immunol. 2018 Apr 26.
9. Honjo S, Murakami Y, Odajima H, Adachi Y, Yoshida K, Ohya Y, Akasawa A. An independent relation of atopic dermatitis to exercise-induced wheezing in asthmatic children. Allergol Int. 2018 May 29.
10. Ogawa K, Tanaka S, Yang L, Arata N, Sago H, Yamamoto-Hanada K, Narita M, Ohya Y: Reply to Matsubara et al. Pediatr Allergy Immunol. 2018 May;29(3):333-334.
11. Saito M, Yamamoto-Hanada K, Pak K, Ayabe T, Mezawa H, Ishitsuka K, Konishi M, Yang L, Matsumoto K, Saito H, Ohya Y: Japan Environment and Children's Study (JECS) Group. Having small-for-gestational-age infants was associated with maternc feal allergiatures in the JECS birth cohort. Allergy. 2018 May 26.in press
12. Mezawa H, Tomotaki A, Yamamoto-Hanada K, Ishitsuka K, Ayabe T, Konishi M, Saito M, Yang L, Suganuma N, Hirahara F, Nakayama S, Saito H, Ohya Y: the Japan Environment and Children's Study (JECS) Group. Prevalence of congenital anomalies in the Japan Environment and Children's Study. Journal of Epidemiology; in press.
13. Inagaki S, Maeda S, Narita M, Nakamura T, Shimosawa T, Murata T, Ohya Y:. Urinary PGDM, a prostaglandin D2 metabolite, is a novel biomarker for objectively detecting allergic reactions of food allergy. J Allergy Clin Immunol. 2018;142(5):1634-1636.
14. Yamamoto-Hanada K, Ohya Y. Self-efficacy of food allergy management in elementary school personnel in Tokyo. Pediatr Int. 2018 Aug;60(8):769-770.
15. Hirota R, Ohya Y, Yamamoto-Hanada K, FukutomiI Y, Muto G, Ngatu-Nlandu R,Nakamura T, Nakamura H. Triclosan-induced Alteration of Gut Microbiome and Aggravation of Asthmatic Airway Response in Aeroallergen-sensitized mice. Allergy. 2018 2018 Oct 24.
16. Yamaguchi C, Ebara T, Hosokawa R, Futamura M, Ohya Y, Asano M. Factors determining parenting stress in mothers of children with atopic dermatitis.Allergol Int. 2018 Sep 11.in press
17. Shimizu Y, Kambayashi Y, Tsujiguchi H, Hara A, Hori D, Thi Thu Nguyen T, Suzuki F, Hamagishi T, Yamada Y, Nakamura H, Yoshikawa T, Hayashi K, Hibino Y, Shibata A, Fukutomi Y, Ohya Y, Yamamoto-Hanada K, Muto G, Hirota R, Konoshita T, Nakamura H. Relationship between the Use of Parabens and Allergic Diseases in Japanese Adults-A Cross-Sectional Study. J 2018; 1: 148-58.
18. Ishitsuka K, Yamamoto-Hanada K, Ayabe T, Mezawa H, Konishi M, Saito M, Ohya Y. Risky Health Behaviors of Teenage Mothers and Infant Outcomes in the Japan Environment and Children's Study: A Nationwide Cohort Study. J Pediatr Adolesc Gynecol. 2018 Nov 2. pii: S1083-3188(18)30348-6.
19. Yamamoto-Hanada K, Kobayashi T, Williams HC, Mikami M, Saito-Abe M, Morita K, Natsume O, Sato M, Iwama M, Miyaji Y, Miyata M, Inagaki S, Tatsuki F, Masami N, Nakayama SF, Kido H, Saito H, Ohya Y. Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACIStudy)-protocol for a randomized controlled trial. Clin Transl Allergy. 2018 Nov 23;8:47.
20. Konishi M, Tomotaki A, Yamamoto-Hanada K, Mezawa H, Ayabe T, Ishitsuka K, Saito M, Saito H, Ohya Y. Sleep status varies by age among Japanese women during preconception and pregnancy in a nationwide birth cohort study [the Japan Environment and Children's Study (JECS)]. Sleep and Biological Rhythms (2018): 1-12.
21. Saito-Abe M, Futamura M, Yamamoto-Hanada K, Yang L,Kohta Suzuki, Ohya Y.Topical corticosteroid phobia among caretakers of children with atopic dermatitis: a cross-sectional study using TOPICOP in Japan. Pediatric Dermatology (2018.Epub ahead of print)

2017

1. Ogawa K, Tanaka S, Limin Y, Arata N, Sago H, Yamamoto-Hanada K, Narita M, OhyaY. Beta-2 receptor agonist exposure in the uterus associated with subsequent risk of childhood asthma. Pediatr Allergy Immunol. 2017 Dec;28(8):746-753.
2. Yamamoto-Hanada K, Yang L, Ishitsuka K, Ayabe T, Mezawa H, Konishi M, Shoda T, Matsumoto K, Saito H, Ohya Y; Japan Environment and Children's Study Group. Allergic profiles of mothers and fathers in the Japan Environment and Children's Study (JECS): a nationwide birth cohort study. World Allergy Organ J. 2017 Aug7;10(1):24.
3. Yamamoto-Hanada K, Yang L, Narita M, Saito H, Ohya Y. Influence of antibiotic use in early childhood on asthma and allergic diseases at age 5. Ann Allergy Asthma Immunol. 2017 Jul;119(1):54-58.
4. Morita H, Suzuki H, Orihara K, Motomura K, Matsuda A, Ohya Y, Saito H, Nomura I, Matsumoto K. Food protein-induced enterocolitis syndromes with and without bloody stool have distinct clinicopathologic features. J Allergy Clin Immunol. 2017 Dec;140(6):1718-1721.e6.
5. Sato S, Yamamoto M, Yanagida N, Ito K, Ohya Y, Imai T, Nagao M, Borres MP, Moverare R, Ebisawa M. Jug r 1 sensitization is important in walnut-allergic children and youth.J Allergy Clin Immunol Pract. 2017 Nov -Dec;5(6):1784-1786.e1.
6. Mitsui M, Shoda T, Natsume O, Nomura I, Narita M, Fukuda A, Sakamoto S, Kasahara M, Ohya Y. Factors Associated with Development of Food Allergy in Young Children after Liver Transplantation: A Retrospective Analysis of 10 Years' Experience. J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1698-1706.
7. Sato M, Shoda T, Shimizu H, Orihara K, Futamura K, Matsuda A, Yamada Y, Irie R, Yoshioka T, Shimizu T, Ohya Y, Nomura I, Matsumoto K, Arai K. Gene Expression Patterns in Distinct Endoscopic Findings for Eosinophilic Gastritis in Children . J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1639-1649.e2.
8. Stickley A, Tachibana Y, Hashimoto K, Haraguchi H, Miyake A, Morokuma S, Nitta H, Oda M, Ohya Y, Senju A, Takahashi H, Yamagata T, Kamio Y. Assessment of Autistic Traits in Children Aged 2 to 4? Years With the Preschool Version of the Social Responsiveness Scale (SRS-P): Findings from Japan. Autism Res. 2017 May;10(5):852-865.
9. Yoshida K, Adachi Y, Sasaki M, Akashi M, Itazawa T, Ohya Y, Odajima H, Akasawa A. Ultraviolet index is associated with childhood eczema prevalence: Sex and age differences. Pediatr Allergy Immunol. 2017 Jun;28(4):391-393.
10. Katayama I, Aihara M, Ohya Y, Saeki H, Shimojo N, Shoji S, Taniguchi M, Yamada H; Japanese Society of Allergology. Japanese guidelines for atopicdermatitis 2017. Allergol Int. 2017 Apr;66(2):230-247.
11. Natsume O, Kabashima S, Nakazato J, Yamamoto-Hanada K, Narita M, Kondo M, Saito M, Kishino A, Takimoto T, Inoue E, Tang J, Kido H, Wong GW, Matsumoto K,Saito H, Ohya Y; PETIT Study Team. Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial. Lancet. 2017 Jan 21;389(10066):276-286.
12. Shoda T, Futamura M, Yang L, Narita M, Saito H, Ohya Y. Yogurt consumption in infancy is inversely associated with atopic dermatitis and food sensitization at 5 years of age: A hospital-based birth cohort study. J Dermatol Sci. 2017 May;86(2):90-96.
13. Akashi M, Yasudo H, Narita M, Nomura I, Akasawa A, Ebisawa M, Takahashi T, Ohya Y. Randomized controlled trial of oral immunotherapy for egg allergy in Japanese patients. Pediatr Int. 2017 May;59(5):534-539.
14. Miyazaki C, Koyama M, Ota E, Swa T, Mlunde LB, Amiya RM, Tachibana Y, Yamamoto-Hanada K, Mori R. Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis. BMC Psychiatry.2017 Mar 31;17(1):120. Iio M, Hamaguchi M, Narita M, Takenaka K, Ohya Y. Tailored education to increase self-efficacy for caregivers of children with asthma. A randomized controlled trial. CIN:Computers, Informatics, Nursing 2017: 35: 36-44.