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Medical Research Center for Japan Environment and Children's Study (JECS)

The Japan Environment and Children's Study (JECS), one of the largest birth cohorts to date enrolling more than 100,000 mother-child pairs, has been conducted nationwide since 2011. Our mission is to support the planning, implementation, and management of the JECS from a medical perspective.

Our missions

The JECS study-also known as the Ecochil survey-aims to investigate the most important aspects of child development by focusing on the environments in which children are brought up. After initial planning by the Ministry of the Environment, recruitment for the survey commenced in 2011, and focused on particular birth cohorts.

The study recruited 100,000 pregnant women over the course of three years in 15 unit centers based at universities and their affiliated hospitals all over Japan. We are now undertaking the most important part of the survey by following-up participants, whereby we track the health of participating children from the intrauterine period up until the age of 13 years.

The National Institute for Environmental Studies (Core Center) plays a central role in administering the survey and is supported by the Medical Support Center, which provides medical expertise in the investigation of the health statuses of mothers and their children.

The survey is being carried out in collaboration with the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labour and Welfare. Moreover, the project supports co-operation with international agencies and the use of data from overseas research institutes.

From 2022, a large scale genetic study of JECS, by genotyping 85,000 children, will begin to improve child health and development typically for those who belong to a genetically vulnerable group to specific environmental contaminants.

Members

Leaders

Researchers

  • Mayako Saito-Abe
  • Miori Sato
  • Minaho Nishizato
  • Yumiko Miyaji
  • Limin Yang
  • Daisuke Harama
  • Kei Sakamoto

Bibliography

2023

  1. Mayako Saito-Abe; Minaho Nishizato; Kiwako Yamamoto-Hanada; Liming Yang; Maki Fukami; Yoshiya Itoh; Kenji Ihara; Atsushi Iwabuchi; Shingo Okamoto; Yasuhiro Naiki; Yukihiro Ohya; and Reiko Horikawa　Comparison of physician-and self-assessed pubertal onset in Japanese children ,Frontier in Pediatrics 2023
  2. Matsumoto, Y., Mochimaru, N., Yasuda, H., Pak, K., Kobayashi, T., Yamamoto-Hanada, K., Ohya, Y., Kiuchi, M., Kurokawa, M. and Yoshida, K. (2023), In vivo analysis of the stratum corneum of Japanese neonates and infants using confocal Raman spectroscopy: a pilot study. Skin Res Technol., 29: e13276.
  3. Yamamoto-Hanada K, Pak K, Saito-Abe M, Sato M, Miyaji Y, Mezawa H, Nishizato M, Yang L, Kumasaka N, Nomura I, Ohya Y; Japan Environment and Children's Study (JECS) Group. Prenatal antibiotic use, caesarean delivery and offspring's food protein-induced enterocolitis syndrome: A National Birth Cohort (JECS). Clin Exp Allergy. 2023 Jan 20.
  4. Kumagai F, Yamamoto-Hanada K, Saito-Abe M, Sato M, Ishikawa F, Irahara M, Irahara M, Miyaji Y, Kabashima S, Ohya Y, Akiyama M. FLG mutations, Eczema Control, and Respiratory Symptom at One-Year-Old in Early-Onset Atopic Dermatitis Infants (PACI-ON Cohort Study). Journal of Dermatological Science. 2023.
  5. Irahara M, Yamamoto-Hanada K, Sato M, Saito-Abe M, Miyaji Y, Yang L, Nishizato M, Kumasaka N, Mezawa H, Ohya Y, on behalf of the Japan Environment and Children's Study (JECS) Group. Relationship between Food Allergy and Endotoxin Concentration and the Toleration Status at 2 Years: The Japan Environment and Children's Study. Nutrients. 2023; 15(4):968.
  6. Yamamoto-Hanada K, Sato M, Toyokuni K, Irahara M, Hiraide-Kotaki E, Harima-Mizusawa N, Morita H, Matsumoto K, Ohya Y. Combination of heat-killed Lactiplantibacillus plantarum YIT 0132 (LP0132) and oral immunotherapy in cow's milk allergy: a randomised controlled trial. Benef Microbes. 2023 Feb 23:1-14.
  7. Yamamoto-Hanada K, Saito-Abe M, Shima K, Fukagawa S, Uehara Y, Ueda Y, Iwamura M, Murase T, Kuwano T, Inoue T, Ohya Y. mRNAs in skin surface lipids unveiled atopic dermatitis at one month. J Eur Acad Dermatol Venereol. 2023 Mar 10.
  8. Kazue Ishitsuka, Kiwako Yamamoto-Hanada, Hidetoshi Mezawa, Mayako Saito-Abe,Hatoko Sasaki1, Minaho Nishizato, Miori Sato, Yukihiro Ohya, Japan Environment and Children's Study Group．Association between pre-pregnancy weight status and dietary patterns during pregnancy: results from the Japan Environment and Children's Study. Public Health Nutrition 2023 May 2;1-8
  9. Limin Yang, Miori Sato, Mayako Saito-Abe, Yumiko Miyaji, Mami Shimada, Chikako Sato, Minaho Nishizato, Natsuhiko Kumasaka, Hidetoshi Mezawa, Kiwako Yamamoto-Hanada, Yukihiro Ohya and The Japan Environment and Children's Study (JECS) Group. Maternal Dietary Zinc Intake during Pregnancy and Childhood Allergic Diseases up to Four Years: The Japan Environment and Children's Study. Nutrients 2023 May 30;15(11):2568
  10. Paller AS, Ladizinski B, Mendes-Bastos P, Siegfried E, Soong W, Prajapati VH, Lio P, Thyssen JP, Simpson EL, Platt AM, Raymundo EM, Liu J, Calimlim BM, Huang X, Gu Y, Hu X, Yang Y, Su JC, Zheng M, Yamamoto-Hanada K, Teixeira HD, Irvine AD. Efficacy and Safety of Upadacitinib Treatment in Adolescents With Moderate-to-Severe Atopic Dermatitis: Analysis of the Measure Up 1, Measure Up 2, and AD Up Randomized Clinical Trials. JAMA Dermatol. 2023 Apr 12:e230391.
  11. Futakawa K, Matsumura K, Tsuchida A, Konishi M, Sasaki H, Mezawa H, Yamamoto-Hanada K, Inadera H, Hasegawa T; Japan Environment and Children's Study (JECS) Group. Longitudinal study of the relationship between number of prior miscarriages or stillbirths and changes in quality of life of pregnant women: the Japan Environment and Children's Study (JECS). BMC Pregnancy Childbirth. 2023 Apr 28;23(1):297.
  12. Tham EH, Leung ASY, Yamamoto-Hanada K, Dahdah L, Trikamjee T, Warad VV, Norris M, Navarrete E, Levina D, Samuel M, van Niekerk A, Martinez S, Ellis AK, Bielory L, van Bever H, Wallace D, Chu DK, Munblit D, Tang ML, Sublett J, Wong GWK. A systematic review of quality and consistency of clinical practice guidelines on the primary prevention of food allergy and atopic dermatitis. World Allergy Organ J. 2023 Apr 25;16(4):100770.
  13. Yuri E. Kram, Miori Sato, Kiwako Yamamoto-Hanada, Kenji Toyokuni, Satoko Uematsu, Takahiro Kudo, Yoshiyuki Yamada, Yoshikazu Ohtsuka, Kenji Matsumoto, Katsuhiro Arai, Tatsuki Fukuie, Ichiro Nomura, Yukihiro Ohya,Development of an action plan for acute food protein-induced enterocolitis syndrome in Japan, World Allergy Organization Journal, 2023．
  14. Yasudo H, Yamamoto-Hanada K, Mikuriya M, Ogino F, Fukuie T, Ohya Y. Association of walnut proteins in household dust with household walnut consumption and Jug r 1 sensitization. Allergology International. 2023.
  15. Limin Yang, Miori Sato, Mayako Saito-Abe, Yumiko Miyaji, Chikako Sato, Minaho Nishizato, Natsuhiko Kumasaka, Hidetoshi Mezawa, Kiwako Yamamoto-Hanada, Yukihiro Ohya and The Japan Environment and Children's Study (JECS) Group. Congenital hypothyroidism and thyroid function in a Japanese birth cohort: data from The Japan Environment and Children's Study. Clinical Pediatric Endocrinology
  16. Fujita N, Mezawa H, Pak K, Uemura O, Yamamoto-Hanada K, Sato M, Saito-Abe M, Miyaji Y, Yang L, Nishizato M, Ohya Y, Ishikura K, Hamasaki Y, Sakai T, Yamamoto K, Ito S, Honda M, Gotoh Y; Japan Environment, Children's Study Group. Reference blood pressure values obtained using the auscultation method for 2-year-old Japanese children: from the Japan Environment and Children's Study. Clin Exp Nephrol. 2023 Jun 30.
  17. Inuzuka Y, Yamamoto-Hanada K, Kobayashi T, Pak K, Toyokuni K, Ogita H, Miyoshi T, Ogawa K, Sago H, Ohya Y: Prevention of Atopic Dermatitis in High-risk Neonates via Different Types of Moisturizer Application; a Randomized, Blinded, Parallel, Three-group, Phase II Trial (PAF study). J Eur Acad Dermatol Venereol. 2023 Jul 21
  18. Sasaki H, Pak K, Mezawa H, Yamamoto-Hanada K, Ishitsuka K, Konishi M, Nishizato M, Sato M, Saito-Abe M, Yang L, Ohya Y ; Japan Environment, Children's Study (JECS) Group: Health-related quality of life of mothers and developmental characteristics of very low birth weight children at 2.5 years of age; results from the Japan Environment and Children's Study (JECS). Health Qual Life Outcomes. 2023 Jul 10;21(1):68.
  19. Miyaji Y, Yamamoto-Hanada K, Yang L, Saito-Abe M, Sato M, Mezawa H, Nishizato M, Ochiai M, Ohga S, Oda M, Mitsubuchi H, Shimono M, Suga R, Mise N, Sekiyama M, Nakayama SF, Ohya Y; Japan Environment and Children's Study (JECS). Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children's Study cohort. BMC Pediatr. 2023 Sep 21;23(1):479.
  20. Yamamoto M, Mezawa H, Sakurai K, Mori C, Japan Environment and Children's Study Group. Screen Time and Developmental Performance Among Children at 1-3 Years of Age in the Japan Environment and Children's Study. JAMA Pediatr. Published online September 18, 2023. doi:10.1001/jamapediatrics.2023.3643

2022

  1. Inuzuka Y, Yamamoto-Hanada K, Nakamura T, Shimosawa T, Murata T, Ohya Y. Detection of allergy reactions during oral food challenge using noninvasive urinary prostaglandin D2 metabolites. Clin Exp Allergy. 2022 Jan;52(1):176-179.
  2. Sakamoto, K., Yamamoto-Hanada, K., Kubota, M., Ishiguro, A. and Ohya, Y. (2022), Type B Adverse Drug Reactions to Antibiotics and Antibiotic Allergy in Infants and Children. Pediatrics International. Accepted Author Manuscript e15126.
  3. Irahara M, Yamamoto-Hanada K, Saito-Abe M, Sato M, Miyaji Y, Yang L, Mitsubuchi H, Oda M, Sanefuji M, Ohga S, Ikegami A, Mise N, Suga R, Shimono M, Yamazaki S, Nakayama SF, Ohya Y. Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment & Children's Study of a pilot cohort. Allergol Int. 2022 in press
  4. Yonezawa K, Haruna M, Yamamoto-Hanada K, Ohya Y. Exacerbation and severity of allergic symptoms during pregnancy and their impact on mental health. International Journal of Women's Dermatology. 2022;8(1):e002.
  5. Yamamoto M, Mezawa H, Sakurai K, Mori C. Association between Media Use and Bedtime Delays in Young Children: An Adjunct Study of the Japan Environment and Children's Study. International Journal of Environmental Research and Public Health. 2022; 19(15):9464. https://doi.org/10.3390/ijerph19159464
  6. Kiguchi T, Yamamoto-Hanada K, Saito-Abe M, Fukuie T, Ohya Y. Eczema phenotypes and IgE component sensitization in adolescents: A population-based birth cohort. Allergol Int. 2022 Jun 30:S1323-8930(22)00070-3.
  7. Inuzuka Y, Yamamoto-Hanada K, Pak K, Miyoshi T, Kobayashi T, Ohya Y. Effective Primary Prevention of Atopic Dermatitis in High-Risk Neonates via Moisturizer Application: Protocol for a Randomized, Blinded, Parallel, Three-Group, Phase II Trial (PAF Study). Front Allergy. 2022 Apr 4;3:862620.
  8. Yang L, Sato M, Saito-Abe M, Miyaji Y, Sato C, Nishizato M, Kumasaka N, Mezawa H, Yamamoto-Hanada K, Ohya Y. Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children's Study. Nutrients. 2022; 14(15):3121
  9. Saeki H, Ohya Y, Furuta J, Arakawa H, Ichiyama S, Katsunuma T, Katoh N, Tanaka A, Tsunemi Y, Nakahara T, Nagao M, Narita M, Hide M, Fujisawa T, Futamura M, Masuda K, Matsubara T, Murota H, Yamamoto-Hanada K. English Version of Clinical Practice Guidelines for the Management of Atopic Dermatitis 2021. J Dermatol. 2022 Aug 22.
  10. Saeki H, Ohya Y, Furuta J, Arakawa H, Ichiyama S, Katsunuma T, Katoh N, Tanaka A, Tsunemi Y, Nakahara T, Nagao M, Narita M, Hide M, Fujisawa T, Futamura M, Masuda K, Matsubara T, Murota H, Yamamoto-Hanada K; Committee for Clinical Practice Guidelines for the Management of Atopic Dermatitis 2021, The Japanese Society of Allergology, The Japanese Dermatology Association. Executive summary: Japanese guidelines for atopic dermatitis (ADGL) 2021. Allergol Int. 2022 Sep 2:S1323-8930(22)00078-8.
  11. Agnes Sze Yin Leung, Elizabeth Huiwen Tham, Miny Samuel, Daniel Munblit, Derek K. Chu, Lamia Dahdah, Kiwako Yamamoto-Haneda, Thulja Trikamjee, Vijay Warad, Andre van Niekerk, Santiago Martinez, Anne Ellis, Leonard Bielory, Gustavo Cuadros, Hugo van Bever, Dana Wallace, Mimi Tang, James Sublett, Gary Wing Kin Wong,Quality and consistency of clinical practice guidelines on the prevention of food allergy and atopic dermatitis: Systematic review protocol,World Allergy Organization Journal,Volume 15, Issue 9,2022,
  12. Toshiaki Tanaka, Takuya Sasaki, Kimitoshi Ikeda, Jianzhong Liu, Allan R. Tenorio, Yukihiro Ohya. Growth analysis among adolescents with moderate-to-severe atopic dermatitis receiving upadacitinib in combination with topical corticosteroids in Japan: A case study series from a phase 3, randomized, controlled trial (Rising Up), World Allergy Organization Journal, Volume 15, Issue 9, 2022,
  13. Hiroki Yasudo ,Kiwako Yamamoto-Hanada, Limin Yang, Mayako Saito-Abe, Miori Sato, Yumiko Miyaji, Mami Shimada, Seiko Hirai, Kenji Toyokuni, Fumi Ishikawa, Yusuke Inuzuka, Shigenori Kabashima, Tatsuki Fukuie and Yukihiro Ohya. Pollen Food Allergy Syndrome in Allergic March. Nutrients 2022, 14, 2658.
    https://doi.org/10.3390/nu14132658.
  14. Yang, L.; Sato, M.; Saito-Abe, M.; Miyaji, Y.; Shimada, M.; Sato, C.; Nishizato, M.; Kumasaka, N.; Mezawa, H.; Yamamoto-Hanada, Ohya Y, On Behalf Of The Japan Environment And Children's Study Jecs Group. Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children's Study. Nutrients. 2022; 14(20):4335.
  15. Saito-Abe M, Yamamoto-Hanada K, Pak K, Iwamoto S, Sato M, Miyaji Y, Mezawa H, Nishizato M, Yang L, Kumasaka N, Kobayashi T, Ohya Y, On Behalf Of The Japan Environment And Children's Study Jecs Group. How a Family History of Allergic Diseases Influences Food Allergy in Children: The Japan Environment and Children's Study. Nutrients. 2022 Oct 15;14(20):4323. doi: 10.3390/nu14204323. PMID: 36297007; PMCID: PMC9606927.
  16. Adachi Y, Takizawa T, Futamura M, Fujisawa T, Yoshihara S; Committee for Japanese Pediatric Guideline for the Treatment and Management of Asthma; Japanese Society of Pediatric Allergy and Clinical Immunology; Japanese Society of Allergology. Executive summary: Japanese Pediatric Guideline for the Treatment and Management of Asthma (JPGL) 2020. Allergol Int. 2022 Sep 6:S1323-8930(22)00085-5. doi: 10.1016/j.alit.2022.07.007. Epub ahead of print. PMID: 36085113.
  17. Miyaji Y, Yamamoto-Hanada K, Fukuie T, Narita M, Ohya Y. Risk factors of admission in school children with severe atopic dermatitis. J Dermatol. 2022 Oct 18. doi: 10.1111/1346-8138.16612. Epub ahead of print. PMID: 36258264.
  18. Nishimura K, Yamamoto-Hanada K, Sato M, Toyokuni K, Ogita H, Kiguchi T, Miyagi Y, Inuzuka Y, Saito-Abe M, Irahara M, Ishikawa F, Kabashima S, Miyaji Y, Fukuie T, Nomura I, Ohya Y. Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in Japan. Nutrients. 2022 Oct 7;14(19):4158.
  19. Yamada S, Fujisawa T, Nagao M, Matsuzaki H, Motomura C, Odajima H, Nakamura T, Imai T, Nagakura KI, Yanagida N, Mitomori M, Ebisawa M, Kabashima S, Ohya Y, Habukawa C, Tomiita M, Hirayama M. Risk Factors for Lung Function Decline in Pediatric Asthma under Treatment: A Retrospective, Multicenter, Observational Study. Children (Basel). 2022 Oct 4;9(10):1516.
  20. Kelleher MM, Phillips R, Brown SJ, Cro S, Cornelius V, Carlsen KCL, Skjerven HO, Rehbinder EM, Lowe AJ, Dissanayake E, Shimojo N, Yonezawa K, Ohya Y, Yamamoto-Hanada K, Morita K, Axon E, Cork M, Cooke A, Van Vogt E, Schmitt J, Weidinger S, McClanahan D, Simpson E, Duley L, Askie LM, Williams HC, Boyle RJ. Skin care interventions in infants for preventing eczema and food allergy. Cochrane Database Syst Rev. 2022 Nov 14;11(11):CD013534.
  21. Nagashima S, Yamamoto M, Inuzuka Y, Irahara M, Miyaji Y, Tadaki H, Ito S, Masuda S, Ito Y, Saito Y, Kobayashi S, Morita H, Yoshioka T, Shimizu H, Arai K, Ohya Y, Saito H, Matsumoto K, Nomura I. Tolerability and safety of a new elimination diet for pediatric eosinophilic gastritis and duodenitis. Allergol Int. 2022 Nov 19:S1323-8930(22)00126-5.
  22. Saeki H, Akiyama M, Abe M, Igarashi A, Imafuku S, Ohya Y, Katoh N, Kameda H, Kabashima K, Tsunemi Y, Hide M, Ohtsuki M; Committee for reviewing the Safety of Atopic Dermatitis/Urticaria Treatment, Japanese Dermatological Association. English version of Japanese guidance for the use of oral Janus kinase (JAK) inhibitors in the treatments of atopic dermatitis. J Dermatol. 2022 Nov 22.
  23. Katoh N, Ohya Y, Murota H, Ikeda M, Hu X, Ikeda K, Liu J, Sasaki T, Raymundo EM, Teixeira HD, Saeki H. Safety and Efficacy of Upadacitinib for Atopic Dermatitis in Japan: 2-Year Interim Results from the Phase 3 Rising Up Study. Dermatol Ther (Heidelb). 2022 Nov 19.
  24. Kumasaka N, Rostom R, Huang N, Polanski K, Meyer KB, Patel S, Boyd R, Gomez C, Barnett S, Panousis N, Schwartzentruber J, Ghoussaini M, Lyons P, Calero-Nieto FJ, Göttgens B, Barnes JL, Worlock KB, Yoshida M, Nikolic MZ, Stephenson E, Reynolds G, Haniffa M, Marioni J, Stegle O, Hagai T, Teichmann S. Mapping interindividual dynamics of innate immune response at single-cell resolution. Nat Genet. In press.

2021

  1. Miyagi Y, Yamamoto-Hanada K, Ogita H, Kiguchi T, Inuzuka Y, Toyokuni K, Nishimura K, Irahara M, Ishikawa F, Sato M, Saito-Abe M, Miyaji Y, Kabashima S, Fukuie T, Nomura I, Ohya Y. Avoidance of Hen's Egg Based on IgE Levels Should Be Avoided for Children With Hen's Egg Allergy. Frontiers in Pediatrics 2021; 8.
  2. Ogawa K, Pak K, Yamamoto-Hanada K, Ishitsuka K, Sasaki H, Mezawa H, Saito-Abe M, Sato M, Yang L, Nishizato M, Konishi M, Sago H, Ohya Y; Japan Environment and Children's Study (JECS) Group. Association between maternal vegetable intake during pregnancy and allergy in offspring: Japan Environment and Children's Study. PLoS One. 2021 Jan 28;16(1):e0245782.
  3. S. Inagaki, T. Nakamura, Y. Hamasaki, K. Yamamoto-Hanada, T. Fukuie, M. Narita, T. Shimosawa, T. Murata, Y. Ohya. Prostaglandin D2 metabolite is not a useful clinical indicator for assessing atopic dermatitis. Clinical and Experimental Dermatology (2021) 46, pp130-134.
  4. Kelleher MM, Cro S, Cornelius V, Lodrup Carlsen KC, Skjerven HO, Rehbinder EM, Lowe AJ, Dissanayake E, Shimojo N, Yonezawa K, Ohya Y, Yamamoto-Hanada K, Morita K, Axon E, Surber C, Cork M, Cooke A, Tran L, Van Vogt E, Schmitt J, Weidinger S, McClanahan D, Simpson E, Duley L, Askie LM, Chalmers JR, Williams HC, Boyle RJ. Skin care interventions in infants for preventing eczema and food allergy. Cochrane Database Syst Rev. 2021 Feb 5;2:CD013534.
  5. Kelleher MM, Cro S, Van Vogt E, Cornelius V, Lodrup Carlsen KC, Skjerven HO, Rehbinder EM, Lowe A, Dissanayake E, Shimojo N, Yonezawa K, Ohya Y, Yamamoto-Hanada K, Morita K, Cork M, Cooke A, Simpson EL, McClanahan D, Weidinger S, Schmitt J, Axon E, Tran L, Surber C, Askie LM, Duley L, Chalmers JR, Williams HC, Boyle RJ. Skin care interventions in infants for preventing eczema and food allergy: a Cochrane systematic review and individual participant data meta-analysis. Clin Exp Allergy. 2021 Feb 6.
  6. Saito-Abe M, Yamamoto-Hanada K, Pak K, Sato M, Irahara M, Mezawa H, Sasaki H, Nishizato M, Ishitsuka K, Konishi M, Yang L, Ohya Y, Suzuki K; Japan Environment and Children's Study (JECS) Group. Association of Maternal History of Allergic Features with Preterm Pregnancy Outcomes in the Japan Environment and Children's Study. Int Arch Allergy Immunol. 2021 Feb 18:1-13
  7. Ogita H, Yamamoto-Hanada K, Yoshida K, Uehara O, Funaki Y, Kohta M, Ohya Y. New skin barrier meter for assessing skin barrier functions: A pilot study in healthy human adults. Skin Res Technol. 2021 Feb 19.
  8. Yamamoto-Hanada K, Pak K, Saito-Abe M, Sato M, Ohya Y; Japan Environment and Children's Study (JECS) Group. Better maternal quality of life in pregnancy yields better offspring respiratory outcomes: a birth cohort. Ann Allergy Asthma Immunol. 2021 Feb 24:S1081-1206(21)00137-X.
  9. Limin Yang, Miori Sato, Mayako Saito-Abe, Makoto Irahara, Minaho Nishizato, Hatoko Sasaki, Mizuho Konishi,　Kazue Ishitsuka, Hidetoshi Mezawa, Kiwako Yamamoto-Hanada, Kenji Matsumoto, and Yukihiro Ohya, for the Japan Environment and Children's Study (JECS) Group. Association of Hemoglobin and. Hematocrit Levels during. Pregnancy and Maternal Dietary. Iron Intake with Allergic Diseases in. Children: The Japan Environment and Children's Study (JECS). Nutrients 2021, 13, 810.
  10. Tomoyuki Kiguchi, Kiwako Yamamoto-Hanada, Mayako Saito-Abe, Miori Sato, Makoto Irahara, Hiroya Ogita, Yoshitsune Miyagi, Yusuke Inuzuka, Kenji Toyokuni, Koji Nishimura, Fumi Ishikawa, Yumiko Miyaji, Shigenori Kabashima, Tatsuki Fukuie, Masami Narita, Yukihiro Ohya:　Pollen-food allergy syndrome and component sensitization in adolescents: A Japanese population-based study.　PLOS ONE.　April 14, 2021
  11. Kohno C, Kaneko K, Takahashi K, Ohya Y, Nakajima H, Murashima A. Intrauterine exposure to immunosuppressants influences the development of postnatal allergic diseases. Allergy. 2021 Apr 27.
  12. Yoshida M, Miyahara Y, Orimo K, Kono N, Narita M, Ohya Y, Matsumoto K, Nakagawa S, Ueki S, Morita H, Miyairi I. Eosinophil Extracellular Traps in the Casts of Plastic Bronchitis Associated With Influenza Virus Infection. Chest. 2021 May 7:S0012-3692(21)00884-9.
  13. Yamaguchi C, Ebara T, Futamura M, Ohya Y, Asano M. Do allergic clinical manifestations increase the risk of behavioral problems in children? A cross-sectional study. Pediatr Allergy Immunol. 2021 May 18.
  14. Tanaka A, Morioke S, Ohya Y, Shimojo N, Shinichi A, Shizukawa H, Takahagi S, Kan T, Saito R, Hide M. Time course of disease severity from birth to 19 years old in patients with moderate to severe atopic dermatitis in adulthood. J Dermatol. 2021 May;48(5):e205-e206.
  15. Morita K, Yasudo H, Chiba T, Kitazawa H, Narita M, Yamamoto-Hanada K, Miyai M, Kishimoto J, Shibata M, Hibino T, Ohya Y. Seasonal variability of epidermal Bleomycin Hydrolase activity in healthy children and pediatric patients with atopic dermatitis. J Dermatol Sci. 2021 May;102(2):137-139.
  16. Ishitsuka K, Sasaki S, Mezawa H, Konishi M, Igarashi M, Yamamoto-Hanada K, Nakayama SF, Ohya Y. Dietary supplement use in elementary school children: a Japanese web-based survey. Environ Health Prev Med. 2021 Jun 5;26(1):63.
  17. Inagaki S, Nakamura T, Natsume O, Yamamoto-Hanada K, Fukuie T, Narita M, Shimosawa T, Murata T, Ohya Y. Urinary prostaglandin D2 metabolite appears to be a useful biomarker for evaluating the status of egg oral immunotherapy in children. J Allergy Clin Immunol Pract. 2021 Jul 15:S2213-2198(21)00771-6.
  18. Tanaka A, Morioke S, Ohya Y, Shimojo N, Takahashi M, Tanaka M, Takahagi S, Kan T, Iwamoto K, Saito R, Hide M. Comparison of the time course of atopic dermatitis from birth to 19 years old among generations of patients in Japan. J Dermatol. 2021 Jul 27.
  19. Yamamoto M, Nagashima S, Yamada Y, Murakoshi T, Shimoyama Y, Takahashi S, Seki H, Kobayashi T, Hara Y, Tadaki H, Ishimura N, Ishihara S, Kinoshita Y, Morita H, Ohya Y, Saito H, Matsumoto K, Nomura I. Comparison of Nonesophageal Eosinophilic Gastrointestinal Disorders with Eosinophilic Esophagitis: A Nationwide Survey. J Allergy Clin Immunol Pract. 2021 Sep;9(9):3339-3349.e8.
  20. Yang L, Sato M, Saito-Abe M, Nishizato M, Mezawa H, Yamamoto-Hanada K, Ohya Y, The Japan Environment And Children's Study Jecs Group. Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children's Study. Nutrients. 2021 Aug 12;13(8):2761.
  21. Kaneko K, Ito Y, Ebara T, Kato S, Matsuki T, Tamada H, Sato H, Saitoh S,Sugiura-Ogasawara M, Yamazaki S, Ohya Y, Kishi R, Yaegashi N, Hashimoto K, Mori C, Ito S, Yamagata Z, Inadera H, Nakayama T, Iso H, Shima M, Kurozawa Y, Suganuma N, Kusuhara K, Katoh T, Kamijima M. Association of maternal total cholesterol with SGA or LGA birth at term: The Japan Environment and Children's Study. J Clin Endocrinol Metab. 2021 Aug 20:dgab618. doi: 10.1210/clinem/dgab618. Epub ahead of print. PMID: 34416000.
  22. Inuzuka Y, Yamamoto-Hanada K, Nakamura T, Shimosawa T, Murata T, Ohya Y. Detection of allergic reactions during oral food challenge using noninvasive urinary prostaglandin D2 metabolites. Clin Exp Allergy. 2021 Aug 30.
  23. Igarashi M, Ayabe T, Yamamoto-Hanada K, Matsubara K, Sasaki H, Saito-Abe M, Sato M, Mise N, Ikegami A, Shimono M, Suga R, Ohga S, Sanefuji M, Oda M, Mitsubuchi H, Michikawa T, Yamazaki S, Nakayama S, Ohya Y, Fukami M. Female-dominant estrogen production in healthy young children before adrenarche. Endocr Connect. 2021 Sep 1:EC-21-0134.R1. doi: 10.1530/EC-21-0134.
  24. Yang L, Sato M, Saito-Abe M, Ohya Y, et al. Hypertensive disorders of pregnancy and risk of allergic conditions in children: Findings from the Japan Environment and Children's study (JECS). World Allergy Organization Journal. 2021;14(9).
  25. Saito-Abe M, Yamamoto-Hanada K, Shoji K, Sato M, Irahara M, Taniguchi Y, Sekiyama　M, Mise N, Ikegami A, Shimono M, Suga R, Sanefuji M, Ohga S, Oda M, Mitsubuchi H, Miyairi I, Ohya Y. Measles antibody seropositivity among children with allergic diseases: a cross-sectional study in the Japan Environment & Children's Pilot Study. PlosONE in press
  26. Nagata N, Hamasaki Y, Inagaki S, Nakamura T, Horikami D, Yamamoto-Hanada K, Inuzuka Y, Shimosawa T, Kobayashi K, Narita M, Ohya Y, Murata T. Urinary lipid profile of atopic dermatitis in murine model and human patients. FASEB J. 2021 Nov;35(11):e21949.
  27. Maeda M, Kuwabara Y, Tanaka Y, Nishikido T, Hiraguchi Y, Yamamoto-Hanada K, Okafuji I, Yamada Y, Futamura M, Ebisawa M. Is oral food challenge test useful for avoiding complete elimination of cow's milk in Japanese patients with or suspected of having IgE-dependent cow's milk allergy? Allergol Int. 2021 Sep 27:S1323-8930(21)00105-2.
  28. Murai H, Irahara M, Sugimoto M, Takaoka Y, Takahashi K, Wada T, Yamamoto-Hanada K,Okafuji I, Yamada Y, Futamura M, Ebisawa M. Is oral food challenge useful to avoid complete elimination in Japanese patients diagnosed with or suspected of having IgE-dependent hen's egg allergy? A systematic review. Allergol Int. 2021 Oct 15:S1323-8930(21)00125-8.
  29. Yamamoto-Hanada K, Pak K, Sato M, Kram YE, Takemura Y, Inoue N, Ohya Y. Associations of frequent emollient use with wheeze and asthma in young Japanese children: A survey of well-child visits. Clin Exp Allergy. 2021 Oct 19.
  30. Arafune J, Tsujiguchi H, Hara A, Shimizu Y, Hori D, Nguyen TTT, Suzuki F, Hamagishi　T, Yamada Y, Nakamura H, Yoshikawa T, Hayashi K, Shibata A, Fukutomi Y, Ohya Y, Yamamoto-Hanada K, Muto G, Hirota R, Konoshita T, Kambayashi Y, Nakamura H. Increased Prevalence of Atopic Dermatitis in Children Aged 0-3 Years Highly Exposed to Parabens. Int J Environ Res Public Health. 2021 Nov 6;18(21):11657.
  31. Yasudo H, Yamamoto-Hanada K, Fukuie T, Masayuki Mikuriya, Ogino F, Ohya Y. Food allergens detected in indoor pet fur. J Dermatol Sci. 2021 Nov 2:S0923-1811(21)00256-5.
  32. Yamamoto-Hanada K, Suzuki Y, Yang L, Saito-Abe M, Sato M, Mezawa H, Nishizato M,　Kato N, Ito Y, Hashimoto K, Ohya Y; Japan Environment and Children's Study (JECS) Group. Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort. PLoS One. 2021 Dec 1;16(12):e0260447
  33. Yang L, Sato M, Saito-Abe M, Irahara M, Nishizato M, Sasaki H, Konishi M, Ishitsuka K, Mezawa H, Yamamoto-Hanada K, Ohya Y; Japan Environment and Children's Study (JECS) Group). 25-Hydroxyvitamin D levels among 2-year-old children: findings from the Japan environment and Children's study (JECS). BMC Pediatr. 2021 Dec 2;21(1):539.
  34. Tabata K, Fukuie T, Narita M, Inagaki S, Ohnishi S, Tsuji S, Kubota M, Ishiguro A, Ohya Y. Food-Induced Anaphylaxis among Children Weighing <15 kg: A Single-Center Case Series of the Pediatric Emergency Department. Int Arch Allergy Immunol. 2021 Dec 9:1-10.
  35. Ruoyan, G. A. I., & Hidetoshi, MEZAWA. (2021). Estimates of inpatient costs for preterm and low-birthweight infants in Japan: An exploratory study using the National Database　of Health Insurance Claims. IPSS Working Paper Series, 1-10.

2020

  1. Sasaki, H, Arata, N, Tomotaki, A, Yamamoto-Hanada, K, Mezawa, H, Konishi, M, Ishitsuka, K, Saito-Abe, M, Sato, M, Nishizato, M, Saito, H & Ohya, Y. Time Course of Metabolic Status in Pregnant Women: the Japan Environment and Children's Study (JECS). Journal of Diabetes Investigation. First published:21 February (2020)
  2. Ishitsuka K*, Yamamoto-Hanada K, Mezawa H, Saito-Abe M, Konishi M, Ohya Y, the Japan Environment and Children's Study Group. Determinants of alcohol consumption in women before and after awareness of conception. Maternal and Child Health Journal. 2020 Feb;24(2):165-176.
  3. Ishitsuka K, Sasaki S, Yamamoto-Hanada K, Mezawa H, Konishi M, Ohya Y*, the Japan Environment and Children's Study Group. Changes in dietary intake in pregnant women from periconception to pregnancy in the Japan Environment and Children's Study, a nationwide Japanese birth cohort. Maternal and Child Health Journal. 2020 Mar;24(3):389-400.
  4. Yamamoto-Hanada K, Kawakami E, Saito-Abe M, Sato M, Mitsubuchi H, Oda M, Katoh T, Sanefuji M, Ohga S, Kuwajima M, Mise N, Ikegami A, Kayama F, Senju A, Shimono M, Kusuhara K, Yamazaki S, Nakayama SF, Matsumoto K, Saito H, Ohya Y. Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study. Cytokine. 2020 Mar 6;130:155051.
  5. Yamamoto-Hanada K, Borres MP, Aberg MK, Yang L, Fukuie T, Narita M, Saito H, Ohya Y. IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo. World Allergy Organ J. 2020 Feb 25;13(2):100105
  6. Yamamoto-Hanada K, Takayama IJ, Futamura M, Saito-Abe M, Ohya Y. Prenatal visits for allergy prevention. Ann Allergy Asthma Immunol. 2020 Feb;124(2):198-200.
  7. Saito-Abe M, Yamamoto-Hanada K, Nakayama SF, Hashimoto Y, Natsume O, Fukami M, Hasegawa T, Ohya Y. Reference values for salivary cortisol in heathy young infants by LC-MS/MS. Pediatr Int. 2020 Jan 24.
  8. Ishitsuka K*, Yamamoto-Hanada K, Yang L, Mezawa H, Konishi M, Saito-Abe M, Sasaki H, Nishizato M, Sato M, Koeda T, Ohya Y, Japan Environment Children's Study Group. Association between Blood Lead Exposure and Mental Health in Pregnant Women: Results From the Japan Environment and Children's Study. Neurotoxicology. 2020 Jun 8;79:191-199.
  9. Irahara M, Yamamoto-Hanada K, Yang L, Saito-Abe M, Sato M, Inuzuka Y, Toyokuni K, Nishimura K, Ishikawa F, Miyaji Y, Fukuie T, Narita M, Ohya Y. Impact of swimming school attendance in 3-year-old children with wheeze and rhinitis at age 5 years: A prospective birth cohort study in Tokyo. PLoS One. 2020 Jun 9;15(6):e0234161.
  10. Taniguchi Y, Yamazaki S, Michikawa T, Nakayama SF, Sekiyama M, Nitta H, Mezawa H, Saito-Abe M, Oda M, Mitsubuchi H, Sanefuji M, Ohga S, Mise N, Ikegami A, Shimono M, Suga R. (2020) Associations of dog and cat ownership with wheezing and asthma in children: Pilot study of the Japan Environment and children's study. PLOS ONE 15(5): e0232604.
  11. Sato M, Yamamoto-Hanada K, Tada H, Irahara M, Saito-Abe M, Matsumoto K, Pak K, Kido H, Ohya Y. Diagnostic performance of IgE avidity for hen's egg allergy in young infants. J Allergy Clin Immunol Pract. 2020 Apr 5
  12. Katoh N, Ohya Y, Ikeda M, Ebihara T, Katayama I, Saeki H, Shimojo N, Tanaka A,Nakahara T, Nagao M, Hide M, Fujita Y, Fujisawa T, Futamura M, Masuda K, Murota H, Yamamoto-Hanada K; Committee for Clinical Practice Guidelines for the Management of Atopic Dermatitis 2018, Japanasese Society of Allergology, Japanese Dermatology Association. Japanese guidelines for atopic dermatitis 2020. Allergol Int. 2020 Apr 4. pii: S1323-8930(20)30018-6.
  13. Yamamoto-Hanada K, Kawakami E, Saito-Abe M, Sato M, Mitsubuchi H, Oda M, Katoh T, Sanefuji M, Ohga S, Kuwajima M, Mise N, Ikegami A, Kayama F, Senju A, Shimono M, Kusuhara K, Yamazaki S, Nakayama SF, Matsumoto K, Saito H, Ohya Y. Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study. Cytokine. 2020 Mar 6;130:155051
  14. Yamamoto-Hanada K, Pak K, Saito-Abe M, Yang L, Sato M, Mezawa H, Sasaki H, Nishizato M, Konishi M, Ishitsuka K, Matsumoto K, Saito H, Ohya Y; Japan Environment and Children's Study (JECS) Group. Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan. Environ Health Prev Med. 2020 Jul 7;25(1):27.
  15. Inagaki S, Nakamura T, Hamasaki Y, Yamamoto-Hanada K, Fukuie T, Narita M, Shimosawa T, Murata T, Ohya Y. Prostaglandin D2 metabolite is not a useful clinical indicator for assessing atopic dermatitis. Clin Exp Dermatol. 2020 Jul 23.
  16. Irahara M, Nomura I, Takeuchi I, Yamamoto-Hanada K, Shimizu H, Fukuie T, Yoshioka T, Arai K, Ohya Y. Pediatric patient with eosinophilic esophagitis and pollen-food allergy syndrome. Asia Pac Allergy. 2020 Jul 13;10(3):e28.
  17. Iio M, Miyaji Y, Yamamoto-Hanada K, Narita M, Nagata M, Ohya Y. Beneficial Features of a mHealth Asthma App for Children and Caregivers: Qualitative Study. JMIR Mhealth Uhealth. 2020 Aug 24;8(8):e18506.
  18. Ishitsuka K, Yamamoto-Hanada K, Yang L, Mezawa H, Konishi M, Saito-Abe M, Sasaki H, Nishizato M, Miori Sato, Koeda T, Ohya Y, Japan Environment Children's Study Group. Association between Blood Lead Exposure and Mental Health in Pregnant Women: Results From the Japan Environment and Children's Study. Neurotoxicology. 2020 Jun 8;79:191-199.
  19. Hashimoto, R., Suto, M., Tsuji, M., Sasaki, H., Takehara, K., Ishiguro, A., & Kubota, M. (2020). Use of antipyretics for preventing febrile seizure recurrence in children: a systematic review and meta-analysis. European Journal of Pediatrics, 1-11.
  20. Tachimoto H, Imanari E, Mezawa H, Okuyama M, Urashima T, Hirano D, Gocho N, Urashima M. Effect of Avoiding Cow's Milk Formula at Birth on Prevention of Asthma or Recurrent Wheeze Among Young Children: Extended Follow-up From the ABC Randomized Clinical Trial. JAMA Netw Open. 2020;3(10):e2018534. doi:10.1001/jamanetworkopen.2020.18534
  21. Funaki S, Umehara N, Mezawa H, Kurakazu M, Matsushima S, Arata N, Okamoto A, Sago H. Ultrasonographic assessment of fetal thyroid in Japan: thyroid circumference and distal femoral and proximal tibial ossification. J Med Ultrasonics 47, 603?608 (2020). https://doi.org/10.1007/s10396-020-01043-5
  22. Mayako Saito-Abe, Kiwako Yamamoto-Hanada, Kyongsun Pak, Miori Sato, Makoto Irahara, Hidetoshi Mezawa, Hatoko Sasaki, Minaho Nishizato, Kazue Ishitsuka, Mizuho Konishi, Limin Yang, Yukihiro Ohya, Kohta Suzuki. Association of maternal history of allergic features with preterm pregnancy outcomes in the Japan Environment and Children's Study. Int Arch Allergy Immunol.
  23. Ishitsuka K, Yamawaki K, Horikawa M, Nakadate H, Nagai A, Ishiguro A. Clinical Prognostic Factors in Pediatric Patients with Orthostatic Intolerance. Glob Pediatr Health. 2020 Nov16
  24. Yamamoto-Hanada K, Pak K, Saito-Abe M, Yang L, Sato M, Irahara M, Mezwa H, Sasaki H, Nishizato M, Ishitsuka K, and Ohya Y. Allergy and immunology in young children of Japan: The JECS cohort. World Allergy Organization Journal 2020; 13.
  25. Yang L, Yamamoto-Hanada K, Ishitsuka K, Ayabe T, Mezawa H, Konishi M, Shoda T, Sago H, Saito H, Ohya Y; Japan Environment and Children's Study Group. Medical and surgical complications in pregnancy and obstetric labour complications in the Japan Environment and Children's Study (JECS) cohort: a birth cohort study. J Obstet Gynaecol. 2020 Oct;40(7):918-924.
  26. Suzuki H, Tsutsumi Y, Morita H, Motomura K, Umehara N, Sago H, Ito Y, Arai K, Yoshioka T, Ohya Y, Saito H, Matsumoto K, Nomura I. Cord blood eosinophilia precedes neonatal onset of food-protein-induced enterocolitis syndrome (FPIES). Allergol Int. 2020 Nov 16:S1323-8930(20)30142-8.

2019

  1. Tsuji M, Koriyama C, Ishihara Y, Yamamoto M, Yamamoto-Hanada K, Kanatani K,Bamai YA, Onishi K, Senju A, Araki S, Shibata E, Morokuma S, Sanefuji M, Kitazawa H, Saito M, Umezawa M, Onoda A, Kusuhara K, Tanaka R, Kawamoto T; Japan Environment & Children's Study Group. Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study. J Epidemiol. 2019 Jan 12.
  2. Mitsui-Iwama M, Yamamoto-Hanada K, Fukutomi Y, Hirota R, Muto G, Nakamura T,Yoshikawa T, Nakamura H, Mikami M, Morioka I, Ohya Y. Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study. Asia Pac Allergy. 2019 Jan 21;9(1):e5.
  3. Nagata C, Yang L, Yamamoto-Hanada K, Mezawa H, Ayabe T, Ishizuka K, Konishi M,Ohya Y, Saito H, Sago H; Japan Environment & Children's Study Group. Complications and adverse outcomes in pregnancy and childbirth among women who conceived by assisted reproductive technologies: a nationwide birth cohort study of Japan environment and children's study. BMC Pregnancy Childbirth. 2019 Feb 20;19(1):77.
  4. Saito-Abe M, Futamura M, Yamamoto-Hanada K, Yang L, Suzuki K, Ohya Y. Topical corticosteroid phobia among caretakers of children with atopic dermatitis: Across-sectional study using TOPICOP in Japan. Pediatr Dermatol. 2019 Mar 18.
  5. Irahara M, Shinahara W, Sugimoto M, Ogawa Y, Shitsukawa K, Kubota K, Yang L,Ohya Y, Saito H, Kagami S, Arisawa K, Kido H. Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy. Immun Inflamm Dis. 2019 Mar 11.
  6. Katsunuma T, Fujisawa T, Maekawa T, Akashi K, Ohya Y, Adachi Y, Hashimoto K,Mizuno M, Imai T, Oba MS, Sako M, Ohashi Y, Nakamura H. Low-dose l-isoproterenol versus salbutamol in hospitalized pediatric patients with severe acute exacerbation of asthma: A double-blind, randomized controlled trial. Allergol Int. 2019 Mar 5.
  7. Kitazawa H, Yamamoto-Hanada K, Saito-Abe M, Ayabe T, Mezawa H, Ishitsuka K, Konishi M, Nakayama SF,Michikawa T, Senju A, Tsuji M, Kusuhara K, Sanefuji M, Ohga S, Oda M, Mitsubuchi H, Katoh T, Ikegami A, Mise N, Matsumoto K, Saito H, Ohya Y. Egg antigen was more abundant than mite antigen in children's bedding: Findings of the pilot study of the Japan Environment and Children's Study (JECS). Allergology International 2019. In press
  8. Okuyama M, Mezawa H, Kawai T, Urashima M.Elevated Soluble PD-L1 in Pregnant Women's Serum Suppresses the Immune Reaction.Front Immunol. 2019 Feb 18;10:86. doi: 10.3389/fimmu.2019.00086. eCollection 2019.
  9. Mizuho Konishi, Junko Kamoshida, Hisako Ogasawara, Mieko Takahashi, Yukihiro Ohya.Tentative development of a psychoeducational program for alleviating psychological burden Of mothers of young children with milk allergy Journal of Health Psychology Research. 2019 vol.31, pp183-193.
  10. Emiko Noguchi, Ryota Koseki, Wataru Morii, Moena Ishikawa, Limin Yang, Kiwako Yamamoto-Hanada, Masami Narita, Hirohisa Saito, and Yukihiro Ohya. Effect of filaggrin loss-of-function mutations on atopic dermatitis in young age: a longitudinal birth cohort study.Journal of Human Genetics.
  11. Irahara M, Shinahara W, Sugimoto M, Ogawa Y, Shitsukawa K, Kubota K, Ohya Y, Saito H, Kagami S, Kido H. Ovomucoid-specific IgG4 level in cord blood associates negatively with later sensitization. Pediatr Allergy Immunol. 2019 Aug 23.
  12. Sasaki A, Sugimoto M, Tokaji N, Irahara M, Okamoto K, Uehara H, Kagami S. Efficacy of an elimination diet in a patient with eosinophilic gastroenteritis : a pediatric case with multiple food allergies. J Med Invest. 2019;66(1.2):201-204.
  13. Mezawa, H, Aoki, S, Nakayama, S. F, Nitta, H, Ikeda, N, Kato, K, Tamai, S, Takekoh, M, Sanefuji, M, Ohga, S , Oda, M, Mitsubuchi, H, Senju, A, Kusuhara, , Kuwajima, M, Koeda, T, Ohya, Y. and Hashimoto, K. (2019), Psychometric profiles of the Ages and Stages Questionnaires, Japanese translation. Pediatrics International. Accepted Author Manuscript.
  14. Sato S, Moverare R, Ohya Y, Ito K, Nagao M, Borres MP, Ebisawa M. Ana o 3-specific IgE is a predictive marker for cashew oral food challenge failure. JAllergy Clin Immunol Pract. 2019 May 17.
  15. Katsunuma T, Fujisawa T, Maekawa T, Akashi K, Ohya Y, Adachi Y, Hashimoto K,Mizuno M, Imai T, Oba MS, Sako M, Ohashi Y, Nakamura H. Low-dose l-isoproterenol versus salbutamol in hospitalized pediatric patients with severe acute exacerbation of asthma: A double-blind, randomized controlled trial. Allergol Int. 2019 Mar 5
  16. Noyuri Y, Lopes KS, Shoda T, Ishitsuka K, Kobayashi T, Ota E, Mori R. TNF-α blockers for the treatment of Kawasaki disease in children. Cochrane Database Syst Rev. 2019 Aug 16;8:CD012448.
  17. Urashima M, Mezawa H, Okuyama M, Urashima T, Hirano D, Gocho N, Tachimoto H. Primary Prevention of Cow's Milk Sensitization and Food Allergy by Avoiding Supplementation With Cow's Milk Formula at Birth: A Randomized Clinical Trial. JAMA Pediatr. 2019;173(12):1137-1145.
  18. Limin Yang; Kiwako Yamamoto-Hanada; Kazue Ishitsuka; Tadayuki Ayabe; Hidetoshi Mezawa; Mizuho Konishi; Tetsuo Shoda; Haruhiko Sago; Hirohisa Saito; Yukihiro Ohya; and The Japan Environment and Children's Study Group. Medical and surgical complications in pregnancy and obstetric labour complications in the Japan Environment and Children's Study (JECS) cohort: a birth cohort study. Journal of Obstetrics and Gynaecology. 28 Nov 2019;1-7 .
  19. Kazue Ishitsuka*, Kiwako Yamamoto-Hanada, Tadayuki Ayabe, Hidetoshi Mezawa, Mizuho Konishi, Mayako Saito-Abe, Yukihiro Ohya. Risky health behaviors of teenage mothers and infant outcomes in the Japan environment and children's study: a nationwide cohort study. Journal of Pediatric and Adolescent Gynecology 32(2):146-152,2019.
  20. Yamawaki K*, Ishitsuka K, Suyama S, Suzumura S, Yamashita H, Kanba S. Clinical characteristics of boys with comorbid ASD and ADHD. Pediatrics International 2019.
  21. Katoh N, Ohya Y, Ikeda M, Ebihara T, Katayama I, Saeki H, Shimojo N, Tanaka A, Nakahara T, Nagao M, Hide M, Fujita Y, Fujisawa T, Futamura M, Masuda K, Murota H, Yamamoto-Hanada K. Clinical practice guidelines for the management of atopic dermatitis 2018. J Dermatol. 2019 Oct 9.
  22. Irahara M, Shinahara W, Sugimoto M, Ogawa Y, Shitsukawa K, Kubota K, Ohya Y, Saito H, Kagami S, Kido H. Ovomucoid-specific IgG4 level in cord blood associates negatively with later sensitization. Pediatr Allergy Immunol. 2019 Dec;30(8):857-860.
  23. Sato M, Yamamoto-Hanada K, Yang L, Irahara M, Ishikawa F, Motoko Iwama-Mitsui, Mayako Saito-Abe, Miyaji Y, Inagaki S, Fukuie T, Nomura I, Narita M, Kohta Suzuki Kand Y and Ohya Y. Complementary and alternative medicine and atopic dermatitis in children
  24. Yamamoto-Hanada K, Takayama IJ, Futamura M, Saito-Abe M, Ohya Y.Implementation science into the public - pregnant women need to prenatal visit for allergy prevention? Ann Allergy Asthma Immunol.2019 in press
  25. Miyaji Y, Yang L, Yamamoto-Hanada K, Narita M, Saito H, Ohya Y. Earlier aggressive treatment to shorten the duration of eczema in infants resulted in fewer food allergies at 2 years of age. J Allergy Clin Immunol Pract. 2019 Dec 7.

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