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エコチル調査研究部

研究部紹介

10万人の母子を対象とする出生コホート調査、子どもの健康と環境に関する調査（エコチル調査）が日本全国15か所で実施されております。当研究部では、日本最大規模の出生コホート調査であるエコチル調査を医学的側面からの調査の立案・企画・実施をサポートしています。

研究内容

近年、子どもたちの間で花粉症や食物アレルギーなどのアレルギー疾患や肥満、発達障害などが増加傾向にあります。それらの多くは、身の回りの環境、食事や運動といった生活習慣、遺伝的な性質などが関連しあっているといわれています。これらの関連を解明するために、環境省が2010年度に「エコチル調査」という大規模な国家プロジェクトを開始しました。

コアセンター（国立環境研究所）を中核に全国15か所の拠点にユニットセンターを設置し、調査を実施しています。成育医療研究センター（エコチル調査研究部）は、メディカルサポートセンターとして医学的側面から調査の立案・企画・実施をサポートする役割を担っています。具体的には、医学的検査・精神神経発達検査に関連した調査方法・調査項目の検討、予備研究による検証、実施マニュアル案の作成、研修会等による検査者標準化のためのトレーニング等を担当しています。また、世界各国で行われている子供と環境に関連する調査や国際機関との連携や調査で得られた結果をいち早く社会に還元するため論文執筆などにも力を入れております。

スタッフ

エコチル調査研究部

梅澤 明弘（部長）

生体制御系計測研究プロジェクト

山本 貴和子（チームリーダー）

行動発達系計測研究プロジェクト

目澤 秀俊（チームリーダー）

遺伝子解析研究プロジェクト

熊坂 夏彦（チームリーダー）

部室員

齋藤 麻耶子（研究員）
佐藤 未織（研究員）
西里 美菜保（研究員）
宮地 裕美子（研究員）
羊 利敏（研究員）
原間 大輔（研究員）
坂本 慧（研究員）

業績

2022

  1. Inuzuka Y, Yamamoto-Hanada K, Nakamura T, Shimosawa T, Murata T, Ohya Y. Detection of allergy reactions during oral food challenge using noninvasive urinary prostaglandin D2 metabolites. Clin Exp Allergy. 2022 Jan;52(1):176-179.
  2. Sakamoto, K., Yamamoto-Hanada, K., Kubota, M., Ishiguro, A. and Ohya, Y. (2022), Type B Adverse Drug Reactions to Antibiotics and Antibiotic Allergy in Infants and Children. Pediatrics International. Accepted Author Manuscript e15126.
  3. Irahara M, Yamamoto-Hanada K, Saito-Abe M, Sato M, Miyaji Y, Yang L, Mitsubuchi H, Oda M, Sanefuji M, Ohga S, Ikegami A, Mise N, Suga R, Shimono M, Yamazaki S, Nakayama SF, Ohya Y. Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment & Children's Study of a pilot cohort. Allergol Int. 2022 in press
  4. Yonezawa K, Haruna M, Yamamoto-Hanada K, Ohya Y. Exacerbation and severity of allergic symptoms during pregnancy and their impact on mental health. International Journal of Women's Dermatology. 2022;8(1):e002.
  5. Yamamoto M, Mezawa H, Sakurai K, Mori C. Association between Media Use and Bedtime Delays in Young Children: An Adjunct Study of the Japan Environment and Children's Study. International Journal of Environmental Research and Public Health. 2022; 19(15):9464. https://doi.org/10.3390/ijerph19159464
  6. Kiguchi T, Yamamoto-Hanada K, Saito-Abe M, Fukuie T, Ohya Y. Eczema phenotypes and IgE component sensitization in adolescents: A population-based birth cohort. Allergol Int. 2022 Jun 30:S1323-8930(22)00070-3.
  7. Inuzuka Y, Yamamoto-Hanada K, Pak K, Miyoshi T, Kobayashi T, Ohya Y. Effective Primary Prevention of Atopic Dermatitis in High-Risk Neonates via Moisturizer Application: Protocol for a Randomized, Blinded, Parallel, Three-Group, Phase II Trial (PAF Study). Front Allergy. 2022 Apr 4;3:862620.
  8. Yang L, Sato M, Saito-Abe M, Miyaji Y, Sato C, Nishizato M, Kumasaka N, Mezawa H, Yamamoto-Hanada K, Ohya Y. Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children's Study. Nutrients. 2022; 14(15):3121
  9. Saeki H, Ohya Y, Furuta J, Arakawa H, Ichiyama S, Katsunuma T, Katoh N, Tanaka A, Tsunemi Y, Nakahara T, Nagao M, Narita M, Hide M, Fujisawa T, Futamura M, Masuda K, Matsubara T, Murota H, Yamamoto-Hanada K. English Version of Clinical Practice Guidelines for the Management of Atopic Dermatitis 2021. J Dermatol. 2022 Aug 22.
  10. Saeki H, Ohya Y, Furuta J, Arakawa H, Ichiyama S, Katsunuma T, Katoh N, Tanaka A, Tsunemi Y, Nakahara T, Nagao M, Narita M, Hide M, Fujisawa T, Futamura M, Masuda K, Matsubara T, Murota H, Yamamoto-Hanada K; Committee for Clinical Practice Guidelines for the Management of Atopic Dermatitis 2021, The Japanese Society of Allergology, The Japanese Dermatology Association. Executive summary: Japanese guidelines for atopic dermatitis (ADGL) 2021. Allergol Int. 2022 Sep 2:S1323-8930(22)00078-8.
  11. Agnes Sze Yin Leung, Elizabeth Huiwen Tham, Miny Samuel, Daniel Munblit, Derek K. Chu, Lamia Dahdah, Kiwako Yamamoto-Haneda, Thulja Trikamjee, Vijay Warad, Andre van Niekerk, Santiago Martinez, Anne Ellis, Leonard Bielory, Gustavo Cuadros, Hugo van Bever, Dana Wallace, Mimi Tang, James Sublett, Gary Wing Kin Wong,Quality and consistency of clinical practice guidelines on the prevention of food allergy and atopic dermatitis: Systematic review protocol,World Allergy Organization Journal,Volume 15, Issue 9,2022,
  12. Toshiaki Tanaka, Takuya Sasaki, Kimitoshi Ikeda, Jianzhong Liu, Allan R. Tenorio, Yukihiro Ohya. Growth analysis among adolescents with moderate-to-severe atopic dermatitis receiving upadacitinib in combination with topical corticosteroids in Japan: A case study series from a phase 3, randomized, controlled trial (Rising Up), World Allergy Organization Journal, Volume 15, Issue 9, 2022,
  13. Hiroki Yasudo ,Kiwako Yamamoto-Hanada, Limin Yang, Mayako Saito-Abe, Miori Sato, Yumiko Miyaji, Mami Shimada, Seiko Hirai, Kenji Toyokuni, Fumi Ishikawa, Yusuke Inuzuka, Shigenori Kabashima, Tatsuki Fukuie and Yukihiro Ohya. Pollen Food Allergy Syndrome in Allergic March. Nutrients 2022, 14, 2658.
    https://doi.org/10.3390/nu14132658.
  14. Yang, L.; Sato, M.; Saito-Abe, M.; Miyaji, Y.; Shimada, M.; Sato, C.; Nishizato, M.; Kumasaka, N.; Mezawa, H.; Yamamoto-Hanada, Ohya Y, On Behalf Of The Japan Environment And Children's Study Jecs Group. Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children's Study. Nutrients. 2022; 14(20):4335.
  15. Saito-Abe M, Yamamoto-Hanada K, Pak K, Iwamoto S, Sato M, Miyaji Y, Mezawa H, Nishizato M, Yang L, Kumasaka N, Kobayashi T, Ohya Y, On Behalf Of The Japan Environment And Children's Study Jecs Group. How a Family History of Allergic Diseases Influences Food Allergy in Children: The Japan Environment and Children's Study. Nutrients. 2022 Oct 15;14(20):4323. doi: 10.3390/nu14204323. PMID: 36297007; PMCID: PMC9606927.
  16. Adachi Y, Takizawa T, Futamura M, Fujisawa T, Yoshihara S; Committee for Japanese Pediatric Guideline for the Treatment and Management of Asthma; Japanese Society of Pediatric Allergy and Clinical Immunology; Japanese Society of Allergology. Executive summary: Japanese Pediatric Guideline for the Treatment and Management of Asthma (JPGL) 2020. Allergol Int. 2022 Sep 6:S1323-8930(22)00085-5. doi: 10.1016/j.alit.2022.07.007. Epub ahead of print. PMID: 36085113.
  17. Miyaji Y, Yamamoto-Hanada K, Fukuie T, Narita M, Ohya Y. Risk factors of admission in school children with severe atopic dermatitis. J Dermatol. 2022 Oct 18. doi: 10.1111/1346-8138.16612. Epub ahead of print. PMID: 36258264.
  18. Nishimura K, Yamamoto-Hanada K, Sato M, Toyokuni K, Ogita H, Kiguchi T, Miyagi Y, Inuzuka Y, Saito-Abe M, Irahara M, Ishikawa F, Kabashima S, Miyaji Y, Fukuie T, Nomura I, Ohya Y. Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in Japan. Nutrients. 2022 Oct 7;14(19):4158.
  19. Yamada S, Fujisawa T, Nagao M, Matsuzaki H, Motomura C, Odajima H, Nakamura T, Imai T, Nagakura KI, Yanagida N, Mitomori M, Ebisawa M, Kabashima S, Ohya Y, Habukawa C, Tomiita M, Hirayama M. Risk Factors for Lung Function Decline in Pediatric Asthma under Treatment: A Retrospective, Multicenter, Observational Study. Children (Basel). 2022 Oct 4;9(10):1516.
  20. Kelleher MM, Phillips R, Brown SJ, Cro S, Cornelius V, Carlsen KCL, Skjerven HO, Rehbinder EM, Lowe AJ, Dissanayake E, Shimojo N, Yonezawa K, Ohya Y, Yamamoto-Hanada K, Morita K, Axon E, Cork M, Cooke A, Van Vogt E, Schmitt J, Weidinger S, McClanahan D, Simpson E, Duley L, Askie LM, Williams HC, Boyle RJ. Skin care interventions in infants for preventing eczema and food allergy. Cochrane Database Syst Rev. 2022 Nov 14;11(11):CD013534.
  21. Nagashima S, Yamamoto M, Inuzuka Y, Irahara M, Miyaji Y, Tadaki H, Ito S, Masuda S, Ito Y, Saito Y, Kobayashi S, Morita H, Yoshioka T, Shimizu H, Arai K, Ohya Y, Saito H, Matsumoto K, Nomura I. Tolerability and safety of a new elimination diet for pediatric eosinophilic gastritis and duodenitis. Allergol Int. 2022 Nov 19:S1323-8930(22)00126-5.
  22. Saeki H, Akiyama M, Abe M, Igarashi A, Imafuku S, Ohya Y, Katoh N, Kameda H, Kabashima K, Tsunemi Y, Hide M, Ohtsuki M; Committee for reviewing the Safety of Atopic Dermatitis/Urticaria Treatment, Japanese Dermatological Association. English version of Japanese guidance for the use of oral Janus kinase (JAK) inhibitors in the treatments of atopic dermatitis. J Dermatol. 2022 Nov 22.
  23. Katoh N, Ohya Y, Murota H, Ikeda M, Hu X, Ikeda K, Liu J, Sasaki T, Raymundo EM, Teixeira HD, Saeki H. Safety and Efficacy of Upadacitinib for Atopic Dermatitis in Japan: 2-Year Interim Results from the Phase 3 Rising Up Study. Dermatol Ther (Heidelb). 2022 Nov 19.
  24. Kumasaka N, Rostom R, Huang N, Polanski K, Meyer KB, Patel S, Boyd R, Gomez C, Barnett S, Panousis N, Schwartzentruber J, Ghoussaini M, Lyons P, Calero-Nieto FJ, Göttgens B, Barnes JL, Worlock KB, Yoshida M, Nikolic MZ, Stephenson E, Reynolds G, Haniffa M, Marioni J, Stegle O, Hagai T, Teichmann S. Mapping interindividual dynamics of innate immune response at single-cell resolution. Nat Genet. In press.

2021

  1. Miyagi Y, Yamamoto-Hanada K, Ogita H, Kiguchi T, Inuzuka Y, Toyokuni K, Nishimura K, Irahara M, Ishikawa F, Sato M, Saito-Abe M, Miyaji Y, Kabashima S, Fukuie T, Nomura I, Ohya Y. Avoidance of Hen's Egg Based on IgE Levels Should Be Avoided for Children With Hen's Egg Allergy. Frontiers in Pediatrics 2021; 8.
  2. Ogawa K, Pak K, Yamamoto-Hanada K, Ishitsuka K, Sasaki H, Mezawa H, Saito-Abe M, Sato M, Yang L, Nishizato M, Konishi M, Sago H, Ohya Y; Japan Environment and Children's Study (JECS) Group. Association between maternal vegetable intake during pregnancy and allergy in offspring: Japan Environment and Children's Study. PLoS One. 2021 Jan 28;16(1):e0245782.
  3. S. Inagaki, T. Nakamura, Y. Hamasaki, K. Yamamoto-Hanada, T. Fukuie, M. Narita, T. Shimosawa, T. Murata, Y. Ohya. Prostaglandin D2 metabolite is not a useful clinical indicator for assessing atopic dermatitis. Clinical and Experimental Dermatology (2021) 46, pp130-134.
  4. Kelleher MM, Cro S, Cornelius V, Lodrup Carlsen KC, Skjerven HO, Rehbinder EM, Lowe AJ, Dissanayake E, Shimojo N, Yonezawa K, Ohya Y, Yamamoto-Hanada K, Morita K, Axon E, Surber C, Cork M, Cooke A, Tran L, Van Vogt E, Schmitt J, Weidinger S, McClanahan D, Simpson E, Duley L, Askie LM, Chalmers JR, Williams HC, Boyle RJ. Skin care interventions in infants for preventing eczema and food allergy. Cochrane Database Syst Rev. 2021 Feb 5;2:CD013534.
  5. Kelleher MM, Cro S, Van Vogt E, Cornelius V, Lodrup Carlsen KC, Skjerven HO, Rehbinder EM, Lowe A, Dissanayake E, Shimojo N, Yonezawa K, Ohya Y, Yamamoto-Hanada K, Morita K, Cork M, Cooke A, Simpson EL, McClanahan D, Weidinger S, Schmitt J, Axon E, Tran L, Surber C, Askie LM, Duley L, Chalmers JR, Williams HC, Boyle RJ. Skin care interventions in infants for preventing eczema and food allergy: a Cochrane systematic review and individual participant data meta-analysis. Clin Exp Allergy. 2021 Feb 6.
  6. Saito-Abe M, Yamamoto-Hanada K, Pak K, Sato M, Irahara M, Mezawa H, Sasaki H, Nishizato M, Ishitsuka K, Konishi M, Yang L, Ohya Y, Suzuki K; Japan Environment and Children's Study (JECS) Group. Association of Maternal History of Allergic Features with Preterm Pregnancy Outcomes in the Japan Environment and Children's Study. Int Arch Allergy Immunol. 2021 Feb 18:1-13
  7. Ogita H, Yamamoto-Hanada K, Yoshida K, Uehara O, Funaki Y, Kohta M, Ohya Y. New skin barrier meter for assessing skin barrier functions: A pilot study in healthy human adults. Skin Res Technol. 2021 Feb 19.
  8. Yamamoto-Hanada K, Pak K, Saito-Abe M, Sato M, Ohya Y; Japan Environment and Children's Study (JECS) Group. Better maternal quality of life in pregnancy yields better offspring respiratory outcomes: a birth cohort. Ann Allergy Asthma Immunol. 2021 Feb 24:S1081-1206(21)00137-X.
  9. Limin Yang, Miori Sato, Mayako Saito-Abe, Makoto Irahara, Minaho Nishizato, Hatoko Sasaki, Mizuho Konishi,　Kazue Ishitsuka, Hidetoshi Mezawa, Kiwako Yamamoto-Hanada, Kenji Matsumoto, and Yukihiro Ohya, for the Japan Environment and Children's Study (JECS) Group. Association of Hemoglobin and. Hematocrit Levels during. Pregnancy and Maternal Dietary. Iron Intake with Allergic Diseases in. Children: The Japan Environment and Children's Study (JECS). Nutrients 2021, 13, 810.
  10. Tomoyuki Kiguchi, Kiwako Yamamoto-Hanada, Mayako Saito-Abe, Miori Sato, Makoto Irahara, Hiroya Ogita, Yoshitsune Miyagi, Yusuke Inuzuka, Kenji Toyokuni, Koji Nishimura, Fumi Ishikawa, Yumiko Miyaji, Shigenori Kabashima, Tatsuki Fukuie, Masami Narita, Yukihiro Ohya:　Pollen-food allergy syndrome and component sensitization in adolescents: A Japanese population-based study.　PLOS ONE.　April 14, 2021
  11. Kohno C, Kaneko K, Takahashi K, Ohya Y, Nakajima H, Murashima A. Intrauterine exposure to immunosuppressants influences the development of postnatal allergic diseases. Allergy. 2021 Apr 27.
  12. Yoshida M, Miyahara Y, Orimo K, Kono N, Narita M, Ohya Y, Matsumoto K, Nakagawa S, Ueki S, Morita H, Miyairi I. Eosinophil Extracellular Traps in the Casts of Plastic Bronchitis Associated With Influenza Virus Infection. Chest. 2021 May 7:S0012-3692(21)00884-9.
  13. Yamaguchi C, Ebara T, Futamura M, Ohya Y, Asano M. Do allergic clinical manifestations increase the risk of behavioral problems in children? A cross-sectional study. Pediatr Allergy Immunol. 2021 May 18.
  14. Tanaka A, Morioke S, Ohya Y, Shimojo N, Shinichi A, Shizukawa H, Takahagi S, Kan T, Saito R, Hide M. Time course of disease severity from birth to 19 years old in patients with moderate to severe atopic dermatitis in adulthood. J Dermatol. 2021 May;48(5):e205-e206.
  15. Morita K, Yasudo H, Chiba T, Kitazawa H, Narita M, Yamamoto-Hanada K, Miyai M, Kishimoto J, Shibata M, Hibino T, Ohya Y. Seasonal variability of epidermal Bleomycin Hydrolase activity in healthy children and pediatric patients with atopic dermatitis. J Dermatol Sci. 2021 May;102(2):137-139.
  16. Ishitsuka K, Sasaki S, Mezawa H, Konishi M, Igarashi M, Yamamoto-Hanada K, Nakayama SF, Ohya Y. Dietary supplement use in elementary school children: a Japanese web-based survey. Environ Health Prev Med. 2021 Jun 5;26(1):63.
  17. Inagaki S, Nakamura T, Natsume O, Yamamoto-Hanada K, Fukuie T, Narita M, Shimosawa T, Murata T, Ohya Y. Urinary prostaglandin D2 metabolite appears to be a useful biomarker for evaluating the status of egg oral immunotherapy in children. J Allergy Clin Immunol Pract. 2021 Jul 15:S2213-2198(21)00771-6.
  18. Tanaka A, Morioke S, Ohya Y, Shimojo N, Takahashi M, Tanaka M, Takahagi S, Kan T, Iwamoto K, Saito R, Hide M. Comparison of the time course of atopic dermatitis from birth to 19 years old among generations of patients in Japan. J Dermatol. 2021 Jul 27.
  19. Yamamoto M, Nagashima S, Yamada Y, Murakoshi T, Shimoyama Y, Takahashi S, Seki H, Kobayashi T, Hara Y, Tadaki H, Ishimura N, Ishihara S, Kinoshita Y, Morita H, Ohya Y, Saito H, Matsumoto K, Nomura I. Comparison of Nonesophageal Eosinophilic Gastrointestinal Disorders with Eosinophilic Esophagitis: A Nationwide Survey. J Allergy Clin Immunol Pract. 2021 Sep;9(9):3339-3349.e8.
  20. Yang L, Sato M, Saito-Abe M, Nishizato M, Mezawa H, Yamamoto-Hanada K, Ohya Y, The Japan Environment And Children's Study Jecs Group. Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children's Study. Nutrients. 2021 Aug 12;13(8):2761.
  21. Kaneko K, Ito Y, Ebara T, Kato S, Matsuki T, Tamada H, Sato H, Saitoh S,Sugiura-Ogasawara M, Yamazaki S, Ohya Y, Kishi R, Yaegashi N, Hashimoto K, Mori C, Ito S, Yamagata Z, Inadera H, Nakayama T, Iso H, Shima M, Kurozawa Y, Suganuma N, Kusuhara K, Katoh T, Kamijima M. Association of maternal total cholesterol with SGA or LGA birth at term: The Japan Environment and Children's Study. J Clin Endocrinol Metab. 2021 Aug 20:dgab618. doi: 10.1210/clinem/dgab618. Epub ahead of print. PMID: 34416000.
  22. Inuzuka Y, Yamamoto-Hanada K, Nakamura T, Shimosawa T, Murata T, Ohya Y. Detection of allergic reactions during oral food challenge using noninvasive urinary prostaglandin D2 metabolites. Clin Exp Allergy. 2021 Aug 30.
  23. Igarashi M, Ayabe T, Yamamoto-Hanada K, Matsubara K, Sasaki H, Saito-Abe M, Sato M, Mise N, Ikegami A, Shimono M, Suga R, Ohga S, Sanefuji M, Oda M, Mitsubuchi H, Michikawa T, Yamazaki S, Nakayama S, Ohya Y, Fukami M. Female-dominant estrogen production in healthy young children before adrenarche. Endocr Connect. 2021 Sep 1:EC-21-0134.R1. doi: 10.1530/EC-21-0134.
  24. Yang L, Sato M, Saito-Abe M, Ohya Y, et al. Hypertensive disorders of pregnancy and risk of allergic conditions in children: Findings from the Japan Environment and Children's study (JECS). World Allergy Organization Journal. 2021;14(9).
  25. Saito-Abe M, Yamamoto-Hanada K, Shoji K, Sato M, Irahara M, Taniguchi Y, Sekiyama　M, Mise N, Ikegami A, Shimono M, Suga R, Sanefuji M, Ohga S, Oda M, Mitsubuchi H, Miyairi I, Ohya Y. Measles antibody seropositivity among children with allergic diseases: a cross-sectional study in the Japan Environment & Children's Pilot Study. PlosONE in press
  26. Nagata N, Hamasaki Y, Inagaki S, Nakamura T, Horikami D, Yamamoto-Hanada K, Inuzuka Y, Shimosawa T, Kobayashi K, Narita M, Ohya Y, Murata T. Urinary lipid profile of atopic dermatitis in murine model and human patients. FASEB J. 2021 Nov;35(11):e21949.
  27. Maeda M, Kuwabara Y, Tanaka Y, Nishikido T, Hiraguchi Y, Yamamoto-Hanada K, Okafuji I, Yamada Y, Futamura M, Ebisawa M. Is oral food challenge test useful for avoiding complete elimination of cow's milk in Japanese patients with or suspected of having IgE-dependent cow's milk allergy? Allergol Int. 2021 Sep 27:S1323-8930(21)00105-2.
  28. Murai H, Irahara M, Sugimoto M, Takaoka Y, Takahashi K, Wada T, Yamamoto-Hanada K,Okafuji I, Yamada Y, Futamura M, Ebisawa M. Is oral food challenge useful to avoid complete elimination in Japanese patients diagnosed with or suspected of having IgE-dependent hen's egg allergy? A systematic review. Allergol Int. 2021 Oct 15:S1323-8930(21)00125-8.
  29. Yamamoto-Hanada K, Pak K, Sato M, Kram YE, Takemura Y, Inoue N, Ohya Y. Associations of frequent emollient use with wheeze and asthma in young Japanese children: A survey of well-child visits. Clin Exp Allergy. 2021 Oct 19.
  30. Arafune J, Tsujiguchi H, Hara A, Shimizu Y, Hori D, Nguyen TTT, Suzuki F, Hamagishi　T, Yamada Y, Nakamura H, Yoshikawa T, Hayashi K, Shibata A, Fukutomi Y, Ohya Y, Yamamoto-Hanada K, Muto G, Hirota R, Konoshita T, Kambayashi Y, Nakamura H. Increased Prevalence of Atopic Dermatitis in Children Aged 0-3 Years Highly Exposed to Parabens. Int J Environ Res Public Health. 2021 Nov 6;18(21):11657.
  31. Yasudo H, Yamamoto-Hanada K, Fukuie T, Masayuki Mikuriya, Ogino F, Ohya Y. Food allergens detected in indoor pet fur. J Dermatol Sci. 2021 Nov 2:S0923-1811(21)00256-5.
  32. Yamamoto-Hanada K, Suzuki Y, Yang L, Saito-Abe M, Sato M, Mezawa H, Nishizato M,　Kato N, Ito Y, Hashimoto K, Ohya Y; Japan Environment and Children's Study (JECS) Group. Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort. PLoS One. 2021 Dec 1;16(12):e0260447
  33. Yang L, Sato M, Saito-Abe M, Irahara M, Nishizato M, Sasaki H, Konishi M, Ishitsuka K, Mezawa H, Yamamoto-Hanada K, Ohya Y; Japan Environment and Children's Study (JECS) Group). 25-Hydroxyvitamin D levels among 2-year-old children: findings from the Japan environment and Children's study (JECS). BMC Pediatr. 2021 Dec 2;21(1):539.
  34. Tabata K, Fukuie T, Narita M, Inagaki S, Ohnishi S, Tsuji S, Kubota M, Ishiguro A, Ohya Y. Food-Induced Anaphylaxis among Children Weighing <15 kg: A Single-Center Case Series of the Pediatric Emergency Department. Int Arch Allergy Immunol. 2021 Dec 9:1-10.
  35. Ruoyan, G. A. I., & Hidetoshi, MEZAWA. (2021). Estimates of inpatient costs for preterm and low-birthweight infants in Japan: An exploratory study using the National Database　of Health Insurance Claims. IPSS Working Paper Series, 1-10.

2020

  1. Sasaki, H, Arata, N, Tomotaki, A, Yamamoto‐Hanada, K, Mezawa, H, Konishi, M, Ishitsuka, K, Saito-Abe, M, Sato, M, Nishizato, M, Saito, H & Ohya, Y. Time Course of Metabolic Status in Pregnant Women: the Japan Environment and Children's Study (JECS). Journal of Diabetes Investigation. First published:21 February (2020)
  2. Ishitsuka K*, Yamamoto-Hanada K, Mezawa H, Saito-Abe M, Konishi M, Ohya Y, the Japan Environment and Children's Study Group. Determinants of alcohol consumption in women before and after awareness of conception. Maternal and Child Health Journal. 2020 Feb;24(2):165-176.
  3. Ishitsuka K, Sasaki S, Yamamoto-Hanada K, Mezawa H, Konishi M, Ohya Y*, the Japan Environment and Children's Study Group. Changes in dietary intake in pregnant women from periconception to pregnancy in the Japan Environment and Children's Study, a nationwide Japanese birth cohort. Maternal and Child Health Journal. 2020 Mar;24(3):389-400.
  4. Yamamoto-Hanada K, Kawakami E, Saito-Abe M, Sato M, Mitsubuchi H, Oda M, Katoh T, Sanefuji M, Ohga S, Kuwajima M, Mise N, Ikegami A, Kayama F, Senju A, Shimono M, Kusuhara K, Yamazaki S, Nakayama SF, Matsumoto K, Saito H, Ohya Y. Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study. Cytokine. 2020 Mar 6;130:155051.
  5. Yamamoto-Hanada K, Borres MP, Åberg MK, Yang L, Fukuie T, Narita M, Saito H, Ohya Y. IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo. World Allergy Organ J. 2020 Feb 25;13(2):100105
  6. Yamamoto-Hanada K, Takayama IJ, Futamura M, Saito-Abe M, Ohya Y. Prenatal visits for allergy prevention. Ann Allergy Asthma Immunol. 2020 Feb;124(2):198-200.
  7. Saito-Abe M, Yamamoto-Hanada K, Nakayama SF, Hashimoto Y, Natsume O, Fukami M,　Hasegawa T, Ohya Y. Reference values for salivary cortisol in heathy young　infants by LC-MS/MS. Pediatr Int. 2020 Jan 24.
  8. Ishitsuka K*, Yamamoto-Hanada K, Yang L, Mezawa H, Konishi M, Saito-Abe M, Sasaki H, Nishizato M, Sato M, Koeda T, Ohya Y, Japan Environment Children's Study Group. Association between Blood Lead Exposure and Mental Health in Pregnant Women: Results From the Japan Environment and Children's Study. Neurotoxicology. 2020 Jun 8;79:191-199.
  9. Irahara M, Yamamoto-Hanada K, Yang L, Saito-Abe M, Sato M, Inuzuka Y, Toyokuni K, Nishimura K, Ishikawa F, Miyaji Y, Fukuie T, Narita M, Ohya Y. Impact of swimming school attendance in 3-year-old children with wheeze and rhinitis at age 5 years: A prospective birth cohort study in Tokyo. PLoS One. 2020 Jun 9;15(6):e0234161.
  10. Taniguchi Y, Yamazaki S, Michikawa T, Nakayama SF, Sekiyama M, Nitta H, Mezawa H, Saito-Abe M, Oda M, Mitsubuchi H, Sanefuji M, Ohga S, Mise N, Ikegami A, Shimono M, Suga R. (2020) Associations of dog and cat ownership with wheezing and asthma in children: Pilot study of the Japan Environment and children's study. PLOS ONE 15(5): e0232604.
  11. Sato M, Yamamoto-Hanada K, Tada H, Irahara M, Saito-Abe M, Matsumoto K, Pak K, Kido H, Ohya Y. Diagnostic performance of IgE avidity for hen's egg allergy in young infants. J Allergy Clin Immunol Pract. 2020 Apr 5
  12. Katoh N, Ohya Y, Ikeda M, Ebihara T, Katayama I, Saeki H, Shimojo N, Tanaka A,Nakahara T, Nagao M, Hide M, Fujita Y, Fujisawa T, Futamura M, Masuda K, Murota H, Yamamoto-Hanada K; Committee for Clinical Practice Guidelines for the Management of Atopic Dermatitis 2018, Japanasese Society of Allergology, Japanese Dermatology Association. Japanese guidelines for atopic dermatitis 2020. Allergol Int. 2020 Apr 4. pii: S1323-8930(20)30018-6.
  13. Yamamoto-Hanada K, Kawakami E, Saito-Abe M, Sato M, Mitsubuchi H, Oda M, Katoh T, Sanefuji M, Ohga S, Kuwajima M, Mise N, Ikegami A, Kayama F, Senju A, Shimono M, Kusuhara K, Yamazaki S, Nakayama SF, Matsumoto K, Saito H, Ohya Y. Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study. Cytokine. 2020 Mar 6;130:155051
  14. Yamamoto-Hanada K, Pak K, Saito-Abe M, Yang L, Sato M, Mezawa H, Sasaki H, Nishizato M, Konishi M, Ishitsuka K, Matsumoto K, Saito H, Ohya Y; Japan Environment and Children's Study (JECS) Group. Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan. Environ Health Prev Med. 2020 Jul 7;25(1):27.
  15. Inagaki S, Nakamura T, Hamasaki Y, Yamamoto-Hanada K, Fukuie T, Narita M, Shimosawa T, Murata T, Ohya Y. Prostaglandin D2 metabolite is not a useful clinical indicator for assessing atopic dermatitis. Clin Exp Dermatol. 2020 Jul 23.
  16. Irahara M, Nomura I, Takeuchi I, Yamamoto-Hanada K, Shimizu H, Fukuie T, Yoshioka T, Arai K, Ohya Y. Pediatric patient with eosinophilic esophagitis and pollen-food allergy syndrome. Asia Pac Allergy. 2020 Jul 13;10(3):e28.
  17. Iio M, Miyaji Y, Yamamoto-Hanada K, Narita M, Nagata M, Ohya Y. Beneficial Features of a mHealth Asthma App for Children and Caregivers: Qualitative Study. JMIR Mhealth Uhealth. 2020 Aug 24;8(8):e18506.
  18. Ishitsuka K, Yamamoto-Hanada K, Yang L, Mezawa H, Konishi M, Saito-Abe M, Sasaki H, Nishizato M, Miori Sato, Koeda T, Ohya Y, Japan Environment Children's Study Group. Association between Blood Lead Exposure and Mental Health in Pregnant Women: Results From the Japan Environment and Children's Study. Neurotoxicology. 2020 Jun 8;79:191-199.
  19. Hashimoto, R., Suto, M., Tsuji, M., Sasaki, H., Takehara, K., Ishiguro, A., & Kubota, M. (2020). Use of antipyretics for preventing febrile seizure recurrence in children: a systematic review and meta-analysis. European Journal of Pediatrics, 1-11.
  20. Tachimoto H, Imanari E, Mezawa H, Okuyama M, Urashima T, Hirano D, Gocho N, Urashima M. Effect of Avoiding Cow's Milk Formula at Birth on Prevention of Asthma or Recurrent Wheeze Among Young Children: Extended Follow-up From the ABC Randomized Clinical Trial. JAMA Netw Open. 2020;3(10):e2018534. doi:10.1001/jamanetworkopen.2020.18534
  21. Funaki S, Umehara N, Mezawa H, Kurakazu M, Matsushima S, Arata N, Okamoto A, Sago H. Ultrasonographic assessment of fetal thyroid in Japan: thyroid circumference and distal femoral and proximal tibial ossification. J Med Ultrasonics 47, 603-608 (2020). https://doi.org/10.1007/s10396-020-01043-5
  22. Mayako Saito-Abe, Kiwako Yamamoto-Hanada, Kyongsun Pak, Miori Sato, Makoto Irahara, Hidetoshi Mezawa, Hatoko Sasaki, Minaho Nishizato, Kazue Ishitsuka, Mizuho Konishi, Limin Yang, Yukihiro Ohya, Kohta Suzuki. Association of maternal history of allergic features with preterm pregnancy outcomes in the Japan Environment and Children's Study. Int Arch Allergy Immunol.
  23. Ishitsuka K, Yamawaki K, Horikawa M, Nakadate H, Nagai A, Ishiguro A. Clinical Prognostic Factors in Pediatric Patients with Orthostatic Intolerance. Glob Pediatr Health. 2020 Nov16
  24. Yamamoto-Hanada K, Pak K, Saito-Abe M, Yang L, Sato M, Irahara M, Mezwa H, Sasaki H, Nishizato M, Ishitsuka K, and Ohya Y. Allergy and immunology in young children of Japan: The JECS cohort. World Allergy Organization Journal 2020; 13.
  25. Yang L, Yamamoto-Hanada K, Ishitsuka K, Ayabe T, Mezawa H, Konishi M, Shoda T, Sago H, Saito H, Ohya Y; Japan Environment and Children's Study Group. Medical and surgical complications in pregnancy and obstetric labour complications in the Japan Environment and Children's Study (JECS) cohort: a birth cohort study. J Obstet Gynaecol. 2020 Oct;40(7):918-924.
  26. Suzuki H, Tsutsumi Y, Morita H, Motomura K, Umehara N, Sago H, Ito Y, Arai K, Yoshioka T, Ohya Y, Saito H, Matsumoto K, Nomura I. Cord blood eosinophilia precedes neonatal onset of food-protein-induced enterocolitis syndrome (FPIES). Allergol Int. 2020 Nov 16:S1323-8930(20)30142-8.

2019

  1. Tsuji M, Koriyama C, Ishihara Y, Yamamoto M, Yamamoto-Hanada K, Kanatani K,Bamai YA, Onishi K, Senju A, Araki S, Shibata E, Morokuma S, Sanefuji M, Kitazawa H, Saito M, Umezawa M, Onoda A, Kusuhara K, Tanaka R, Kawamoto T; Japan Environment & Children's Study Group. Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study. J Epidemiol. 2019 Jan 12.
  2. Mitsui-Iwama M, Yamamoto-Hanada K, Fukutomi Y, Hirota R, Muto G, Nakamura T,Yoshikawa T, Nakamura H, Mikami M, Morioka I, Ohya Y. Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study. Asia Pac Allergy. 2019 Jan 21;9(1):e5.
  3. Nagata C, Yang L, Yamamoto-Hanada K, Mezawa H, Ayabe T, Ishizuka K, Konishi M,Ohya Y, Saito H, Sago H; Japan Environment & Children's Study Group. Complications and adverse outcomes in pregnancy and childbirth among women who conceived by assisted reproductive technologies: a nationwide birth cohort study of Japan environment and children's study. BMC Pregnancy Childbirth. 2019 Feb 20;19(1):77.
  4. Saito-Abe M, Futamura M, Yamamoto-Hanada K, Yang L, Suzuki K, Ohya Y. Topical corticosteroid phobia among caretakers of children with atopic dermatitis: Across-sectional study using TOPICOP in Japan. Pediatr Dermatol. 2019 Mar 18.
  5. Irahara M, Shinahara W, Sugimoto M, Ogawa Y, Shitsukawa K, Kubota K, Yang L,Ohya Y, Saito H, Kagami S, Arisawa K, Kido H. Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy. Immun Inflamm Dis. 2019 Mar 11.
  6. Katsunuma T, Fujisawa T, Maekawa T, Akashi K, Ohya Y, Adachi Y, Hashimoto K,Mizuno M, Imai T, Oba MS, Sako M, Ohashi Y, Nakamura H. Low-dose l-isoproterenol versus salbutamol in hospitalized pediatric patients with severe acute exacerbation of asthma: A double-blind, randomized controlled trial. Allergol Int. 2019 Mar 5.
  7. Kitazawa H, Yamamoto-Hanada K, Saito-Abe M, Ayabe T, Mezawa H, Ishitsuka K, Konishi M, Nakayama SF,Michikawa T, Senju A, Tsuji M, Kusuhara K, Sanefuji M, Ohga S, Oda M, Mitsubuchi H, Katoh T, Ikegami A, Mise N, Matsumoto K, Saito H, Ohya Y. Egg antigen was more abundant than mite antigen in children's bedding: Findings of the pilot study of the Japan Environment and Children's Study (JECS). Allergology International 2019. In press
  8. Okuyama M, Mezawa H, Kawai T, Urashima M.Elevated Soluble PD-L1 in Pregnant Women's Serum Suppresses the Immune Reaction.Front Immunol. 2019 Feb 18;10:86. doi: 10.3389/fimmu.2019.00086. eCollection 2019. 　　　
  9. Mizuho Konishi, Junko Kamoshida, Hisako Ogasawara, Mieko Takahashi, Yukihiro Ohya.Tentative development of a psychoeducational program for alleviating psychological burden Of mothers of young children with milk allergy Journal of Health Psychology Research. 2019 vol.31, pp183-193.
  10. Emiko Noguchi, Ryota Koseki, Wataru Morii, Moena Ishikawa, Limin Yang, Kiwako Yamamoto-Hanada, Masami Narita, Hirohisa Saito, and Yukihiro Ohya. Effect of filaggrin loss-of-function mutations on atopic dermatitis in young age: a longitudinal birth cohort study.　Journal of Human Genetics.　
  11. Irahara M, Shinahara W, Sugimoto M, Ogawa Y, Shitsukawa K, Kubota K, Ohya Y, Saito H, Kagami S, Kido H. Ovomucoid-specific IgG4 level in cord blood associates negatively with later sensitization. Pediatr Allergy Immunol. 2019 Aug 23.
  12. Sasaki A, Sugimoto M, Tokaji N, Irahara M, Okamoto K, Uehara H, Kagami S. Efficacy of an elimination diet in a patient with eosinophilic gastroenteritis : a pediatric case with multiple food allergies. J Med Invest. 2019;66(1.2):201-204.
  13. Mezawa, H, Aoki, S, Nakayama, S. F, Nitta, H, Ikeda, N, Kato, K, Tamai, S, Takekoh, M, Sanefuji, M, Ohga, S , Oda, M, Mitsubuchi, H, Senju, A, Kusuhara, , Kuwajima, M, Koeda, T, Ohya, Y. and Hashimoto, K. (2019), Psychometric profiles of the Ages and Stages Questionnaires, Japanese translation. Pediatrics International. Accepted Author Manuscript.
  14. Sato S, Movérare R, Ohya Y, Ito K, Nagao M, Borres MP, Ebisawa M. Ana o 3-specific IgE is a predictive marker for cashew oral food challenge failure. JAllergy Clin Immunol Pract. 2019 May 17.
  15. Katsunuma T, Fujisawa T, Maekawa T, Akashi K, Ohya Y, Adachi Y, Hashimoto K,Mizuno M, Imai T, Oba MS, Sako M, Ohashi Y, Nakamura H. Low-dose l-isoproterenol versus salbutamol in hospitalized pediatric patients with severe acute exacerbation of asthma: A double-blind, randomized controlled trial. Allergol Int. 2019 Mar 5
  16. Noyuri Y, Lopes KS, Shoda T, Ishitsuka K, Kobayashi T, Ota E, Mori R. TNF-α blockers for the treatment of Kawasaki disease in children. Cochrane Database Syst Rev. 2019 Aug 16;8:CD012448.
  17. Urashima M, Mezawa H, Okuyama M, Urashima T, Hirano D, Gocho N, Tachimoto H. Primary Prevention of Cow's Milk Sensitization and Food Allergy by Avoiding Supplementation With Cow's Milk Formula at Birth: A Randomized Clinical Trial. JAMA Pediatr. 2019;173(12):1137-1145.
  18. Limin Yang; Kiwako Yamamoto-Hanada; Kazue Ishitsuka; Tadayuki Ayabe; Hidetoshi Mezawa; Mizuho Konishi; Tetsuo Shoda; Haruhiko Sago; Hirohisa Saito; Yukihiro Ohya; and The Japan Environment and Children's Study Group. Medical and surgical complications in pregnancy and obstetric labour complications in the Japan Environment and Children's Study (JECS) cohort: a birth cohort study. Journal of Obstetrics and Gynaecology. 28 Nov 2019；1-7 .
  19. Kazue Ishitsuka*, Kiwako Yamamoto-Hanada, Tadayuki Ayabe, Hidetoshi Mezawa, Mizuho Konishi, Mayako Saito-Abe, Yukihiro Ohya. Risky health behaviors of teenage mothers and infant outcomes in the Japan environment and children's study: a nationwide cohort study. Journal of Pediatric and Adolescent Gynecology 32(2):146-152,2019.
  20. Yamawaki K*, Ishitsuka K, Suyama S, Suzumura S, Yamashita H, Kanba S. Clinical characteristics of boys with comorbid ASD and ADHD. Pediatrics International 2019.
  21. Katoh N, Ohya Y, Ikeda M, Ebihara T, Katayama I, Saeki H, Shimojo N, Tanaka A, Nakahara T, Nagao M, Hide M, Fujita Y, Fujisawa T, Futamura M, Masuda K, Murota H, Yamamoto-Hanada K. Clinical practice guidelines for the management of atopic dermatitis 2018. J Dermatol. 2019 Oct 9.
  22. Irahara M, Shinahara W, Sugimoto M, Ogawa Y, Shitsukawa K, Kubota K, Ohya Y, Saito H, Kagami S, Kido H.　Ovomucoid-specific IgG4 level in cord blood associates negatively with later sensitization. Pediatr Allergy Immunol. 2019 Dec;30(8):857-860.
  23. Sato M, Yamamoto-Hanada K, Yang L, Irahara M, Ishikawa F, Motoko Iwama-Mitsui, Mayako Saito-Abe, Miyaji Y, Inagaki S, Fukuie T, Nomura I, Narita M, Kohta Suzuki Kand Y and Ohya Y.　Complementary and alternative medicine and atopic dermatitis in children
  24. Yamamoto-Hanada K, Takayama IJ, Futamura M, Saito-Abe M, Ohya Y.Implementation science into the public - pregnant women need to prenatal visit for allergy prevention? Ann Allergy Asthma Immunol.2019 in press
  25. Miyaji Y, Yang L, Yamamoto-Hanada K, Narita M, Saito H, Ohya Y. Earlier aggressive treatment to shorten the duration of eczema in infants resulted in fewer food allergies at 2 years of age. J Allergy Clin Immunol Pract. 2019 Dec 7.

2018

  1. Yamamoto-Hanada K, Ishitsuka K, Pak K, Saito M, Ayabe T, Mezawa H, Konishi M, Yang L, Matsumoto K, Saito H, Ohya Y; Japan Environment and Children's Study (JECS) Group: Allergy and mental health among pregnant women in the Japan Environment and Children's Study. J Allergy Clin Immunol Pract. 2018 Jan 20. pii:S2213-2198(17)31024-3.
  2. Natsume O, Ohya Y. Recent advancement to prevent the development of allergy and allergic diseases and therapeutic strategy in the perspective of barrier dysfunction: Allergol Int. 2018 Jan;67(1):24-31.
  3. Ayabe T, Yamamoto-Hanada K, Mezawa H, Konishi M, Ishitsuka K, Saito M, Fukami M, Michikawa T, Yamazaki S, Senju A, Kusuhara K, Kawamoto T, Sanefuji M, Kato K, Oda M, Mitsubuchi H, Katoh T, Monden Y, Mise N, Kayama F, Saito H, Ohya Y: Regional differences in infant 25-Hydroxyvitamin D: Pilot study of the Japan Environment and Children's Study. Pediatr Int. 2018 Jan;60(1):30-34.
  4. Mito A, Arata N, Qiu D, Sakamoto N, Murashima A, Ichihara A, Matsuoka R, Sekizawa A, Ohya Y, Kitagawa M: Hypertensive disorders of pregnancy: a strong risk factor for subsequent hypertension 5 years after delivery. Hypertens Res. 2018 Feb;41(2):141-146.
  5. Nagao M, Inagaki S, Kawano T, Azuma Y, Nomura N, Noguchi Y, Ohta S, Kawaguchi A, Odajima H, Ohya Y, Fujisawa T, Izuhara K: SCCA2 is a reliable biomarker for evaluating pediatric atopic dermatitis. J Allergy Clin Immunol. 2018 Feb 5.
  6. Aoki S, Hashimoto K, Mezawa H, Hatakenaka Y, Yasumitsu-Lovell K, Suganuma N, Ohya Y, Wilson P, Fernell E, Kamio Y, Gillberg C. Development of a new screening tool for neuromotor development in hildren aged two - the neuromotor 5 min exam 2-year-old version (N5E2). Brain Dev. 2018;40: 445-451.
  7. Matsumoto K, Mori R, Miyazaki C, Ohya Y, Saito H. Are both early egg introduction and eczema treatment necessary for primary prevention of egg allergy? : J Allergy Clin Immunol. 2018 Mar 6.
  8. Yang L, Narita M, Yamamoto-Hanada K, Sakamoto N, Saito H, Ohya Y. Phenotypes of Childhood Wheeze in Japanese children: A Group-Based Trajectory Analysis. Pediatr Allergy Immunol. 2018 Apr 26.
  9. Honjo S, Murakami Y, Odajima H, Adachi Y, Yoshida K, Ohya Y, Akasawa A. An independent relation of atopic dermatitis to exercise-induced wheezing in asthmatic children. Allergol Int. 2018 May 29.
  10. Ogawa K, Tanaka S, Yang L, Arata N, Sago H, Yamamoto-Hanada K, Narita M, Ohya Y: Reply to Matsubara et al. Pediatr Allergy Immunol. 2018 May;29(3):333-334.
  11. Saito M, Yamamoto-Hanada K, Pak K, Ayabe T, Mezawa H, Ishitsuka K, Konishi M, Yang L, Matsumoto K, Saito H, Ohya Y: Japan Environment and Children's Study (JECS) Group. Having small-for-gestational-age infants was associated with maternc feal allergiatures in the JECS birth cohort. Allergy. 2018 May 26.in press
  12. Mezawa H, Tomotaki A, Yamamoto-Hanada K, Ishitsuka K, Ayabe T, Konishi M, Saito M, Yang L, Suganuma N, Hirahara F, Nakayama S, Saito H, Ohya Y: the Japan Environment and Children's Study (JECS) Group. Prevalence of congenital anomalies in the Japan Environment and Children's Study. Journal of Epidemiology; in press.
  13. Inagaki S, Maeda S, Narita M, Nakamura T, Shimosawa T, Murata T, Ohya Y:. Urinary PGDM, a prostaglandin D2 metabolite, is a novel biomarker for objectively detecting allergic reactions of food allergy. J Allergy Clin Immunol. 2018;142(5):1634-1636.
  14. Yamamoto-Hanada K, Ohya Y. Self-efficacy of food allergy management in elementary school personnel in Tokyo. Pediatr Int. 2018 Aug;60(8):769-770.
  15. Hirota R, Ohya Y, Yamamoto-Hanada K, FukutomiI Y, Muto G, Ngatu-Nlandu R,Nakamura T, Nakamura H. Triclosan-induced Alteration of Gut Microbiome and Aggravation of Asthmatic Airway Response in Aeroallergen-sensitized mice. Allergy. 2018 2018 Oct 24.
  16. Yamaguchi C, Ebara T, Hosokawa R, Futamura M, Ohya Y, Asano M. Factors determining parenting stress in mothers of children with atopic dermatitis.Allergol Int. 2018 Sep 11.in press
  17. Shimizu Y, Kambayashi Y, Tsujiguchi H, Hara A, Hori D, Thi Thu Nguyen T, Suzuki F, Hamagishi T, Yamada Y, Nakamura H, Yoshikawa T, Hayashi K, Hibino Y, Shibata A, Fukutomi Y, Ohya Y, Yamamoto-Hanada K, Muto G, Hirota R, Konoshita T, Nakamura H.　Relationship between the Use of Parabens and Allergic Diseases in Japanese Adults--A Cross-Sectional Study. J 2018; 1: 148-58.
  18. Ishitsuka K, Yamamoto-Hanada K, Ayabe T, Mezawa H, Konishi M, Saito M, Ohya Y. Risky Health Behaviors of Teenage Mothers and Infant Outcomes in the Japan Environment and Children's Study: A Nationwide Cohort Study. J Pediatr Adolesc Gynecol. 2018 Nov 2. pii: S1083-3188(18)30348-6.
  19. Yamamoto-Hanada K, Kobayashi T, Williams HC, Mikami M, Saito-Abe M, Morita K, Natsume O, Sato M, Iwama M, Miyaji Y, Miyata M, Inagaki S, Tatsuki F, Masami N, Nakayama SF, Kido H, Saito H, Ohya Y. Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACIStudy)-protocol for a randomized controlled trial. Clin Transl Allergy. 2018 Nov 23;8:47.
  20. Konishi M, Tomotaki A, Yamamoto-Hanada K, Mezawa H, Ayabe T, Ishitsuka K, Saito M, Saito H, Ohya Y. Sleep status varies by age among Japanese women during preconception and pregnancy in a nationwide birth cohort study [the Japan Environment and Children's Study (JECS)]. Sleep and Biological Rhythms (2018): 1-12.
  21. Saito-Abe M, Futamura M, Yamamoto-Hanada K, Yang L,Kohta Suzuki, Ohya Y.Topical corticosteroid phobia among caretakers of children with atopic dermatitis: a cross-sectional study using TOPICOP in Japan. Pediatric Dermatology (2018.Epub ahead of print)

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