免疫アレルギー・感染研究部

研究部紹介

気管支喘息、アトピー性皮膚炎、食物アレルギー、川崎病といった様々な免疫アレルギー疾患や、移植時の拒絶反応、先天性サイトメガロウイルス感染症をはじめとした母児感染症や重症感染症が発生する仕組みについて、疫学研究・臨床研究・基礎研究の手法を駆使して解明し、これらの疾患に対する有効な予防・治療および診断法の開発を最終的な目標として研究を行っています。

　アレルギー疾患を発症する小児の割合は近年増加傾向にあります。このようなアレルギー疾患の増加には、主として環境因子と遺伝的素因が大きく関与していると考えられています。アレルギー研究室では、アレルギー疾患の発症や重症化の仕組みを明らかにし、それを応用した新たな発症予防法の開発を目指して研究を行っています。特に、近年新たに発見された自然リンパ球と組織構成細胞との相互作用に着目し、研究を行っています。また、近年報告が増えている好酸球性消化管疾患に関する病態解明研究も行なっています。

　川崎病は乳幼児に好発する原因不明の全身性血管炎です。特に、心臓に血液を供給する冠動脈の炎症による後遺症（冠動脈瘤の形成）を残すことが臨床上最も重要な問題となります。冠動脈障害が原因で心筋梗塞を起こすこともあり、小児の後天性心疾患の原因の一つです。また、未だ川崎病の病因や発症メカニズムが解明されていない中、日本の年間患者発生数は世界一多く、年々増加していることも疫学調査から明らかになっています。炎症制御研究室では、川崎病の急性期標準治療として用いられている免疫グロブリン療法（IVIG）の冠動脈炎症に対する抗炎症効果の作用機序について、分子細胞生物学的手法を用いた解明を目指しています。この研究成果は、IVIG治療抵抗例のような重症川崎病患者に対する新たな治療戦略の確立に役立つと考えています。

　移植免疫研究室では、様々な臓器移植モデル、やIn vitroの評価系を用いて、免疫寛容の誘導・維持に関与する分子・細胞の機序の解明およびCell Based Therapy を中心に、制御性T細胞、iPS細胞由来制御性樹状細胞（DC）、ミエロイド由来抑制細胞（MDSC）、間葉系幹細胞を用いる免疫制御細胞療法を確立するための基礎研究を行っています。また、新規免疫抑制剤、新規臓器保存法の開発を積極的に進めています。
母児感染研究室では、先天性サイトメガロウイルス感染症をはじめとした母児感染症について、新規感染モデルの確立、病原性発現機構の解明、および新規診断・治療法開発に向けた研究を行っています。

　感染症は、小児が罹患する疾患として最も頻度の高いものです。また、免疫不全症をはじめとする慢性疾患や手術後の患者における合併症としても感染症は重要です。感染免疫研究室ではリアルタイムPCRなどを用いた感染症の診断法の開発および実際の診断を行っています。研究成果は診療への直接の還元のみならず、病態解明や新しい治療法の評価指標として活かされています。

研究内容

研究プロジェクト

• 小児アレルギー疾患の予防・制御方法の開発
• オミックス情報に基づく免疫アレルギー疾患の病態解析研究
• 自然リンパ球の活性制御機構の解明
• 好酸球性消化管疾患の病態解明
• 免疫グロブリン治療の冠動脈炎症に対する抗炎症作用機序の解明
• 重症川崎病患者に対する新規治療法の開発
• 移植免疫寛容の誘導・維持に関与する分子・細胞の機序の解明
• iPS細胞から分化誘導した制御性樹状細胞等を用いた免疫制御細胞療法の確立
• 母児感染症発症機構の解明および新規診断・治療法の開発
• 小児重症感染症の迅速診断法の開発と臨床応用

研究内容

（１）疫学研究

• 横断的研究（因子分析）、コホート研究、エコチル参画
• 責任遺伝子探索（GWAS、候補遺伝子探索・機能解析）

（２）臨床研究

• オミックス情報に基づく免疫アレルギー疾患の病態解析
• 介入研究（乳幼児湿疹や食物感作の予防の試み）
• 乳幼児食物依存性消化管アレルギー/好酸球性消化管疾患の病態解析
• 患者Ｔ細胞応答の検討

（３）基礎研究

• 炎症細胞（自然リンパ球、マスト細胞、好酸球）や組織細胞（上皮細胞、血管内皮細胞等）の活性化・制御に関するin vitro研究
• ノックアウトマウスを用いた病態関連遺伝子の詳細な検討

スタッフ

業績

2021

1. Orimo K, Tamari M, Takeda T, Kubo T, Ruckert B, Motomura K, Sugiyama H, Yamada A, Saito K, Arae K, Kuriyama M, Hara M, Soyk MB, Ikutani M, Yamaguchi S, Morimoto N, Nakabayashi K, Hata K, Matsuda A, Akdis CA, Sudo K,Saito H, Nakae S, Tamaoki J, Tagaya E, Matsumoto K, Morita H. Direct platelet adhesion potentiates group 2 innate lymphoid cell functions. Allergy. 2021;77:843-855
2. Igarashi A, Matsumoto K, Matsuda A. MicroRNA-29s suppressed both soluble ST2 release and IFNAR1 expression in human bronchial epithelial cells. Allergy 2021;76:2264-2267
3. Orimo K, Saito H, Matsumoto K, Morita H. Innate lymphoid cells in the airways: Their functions and regulators. Allergy Asthma Immunol Res 2020;12:381-398.
4. Matsumoto K, Morita H, Nakae S. New insights of human atopic dermatitis provided by mouse models. Journal of Allery and Clinical Immunology. 2021;148:722-724.
5. Morita H. Immunological memory and allergic diseases. Allergology International 2021;70:161-162.
6. Matsumoto K. Valuable lessons from analyses of common signs and symptoms in rare diseases. Allergology International 2021;70:405-406
7. Morita H, Saito H, Matsumoto K. Immune checkpoint molecules on ILC2s as potential therapeutic targets for allergic diseases. J Allergy Clin Immunol. 2022 ;149:60-62
8. Orimo K, Tamari M, Saito H, Matsumoto K, Nakae S, Morita H*. Characteristics of tissue-resident ILCs and their potential as therapeutic targents in mucosal and skin inflammatory diseases. Allergy 2021;76:3332-3348.
9. Boonpiyathad T, Tantilipikorn P, Ruxrungtham K, Pradubpongsa P, Mitthamsiri W, Piedvache A, Thantiworasit P, Sirivichayakul S, Jasquet A, Suratannon N, Chatchatee P, Moritaki N, Saito H, Sangasapaviriya A, Matsumoto K, Morita H. IL-10-producing innate lymphoid cells increased in patients with house dust mite allergic rhinitis following immunotherapy. Journal of Allergy Clinical Immunology. 2021;147:1507-1510.
10. Arae K, Ikutani M, Horiguchi K, Yamaguchi S, Okada Y, Sugiyama H,Orimo K, Morita H, Suto H, Okumura K, Taguchi H, Matsumoto K, Saito H, Sudo K, Nakae S. Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin. Scientific Report 2021;11:5913.
11. Suzuki H, Tsutsumi Y, Morita H, Motomura K, Umehara N, Sago H, Ito Y, Arai K, Yoshida T, Ohya Y, Saito H, Matsumoto K, Nomura I. Cord blood eosinophilia precedes neonatal onset of food-protein-induced enterocolitis syndrome (FPIES). Allergology International. 2021;70:262-265.
12. Toyama Y, Ishii T, Morita K, Tsumura Y, Takahashi T, Akashi M, Morita H. Multicenter retrospective study of patients with food protein-induced enterocolitis syndrome provoked by hen's egg. Journal of Allergy Clinical Immunology in Practice. 2021;9:547-549.
13. Akashi M, Hayashi D, Kajita N, Kinoshita M, Ishii T, Tsumura Y, Horimukai K, Yoshida K, Takahashi T, Morita H. Recent dramatic increase in patients with food protein-induced enterocolitis syndrome (FPIES) provoked by hen's egg in Japan. J Allergy Clin Immunol Pract. 2022;10:1110-1112
14. Yohida M, Miyahara Y, Orimo K, Kono N, Narita M, Ohya Y, Matsumoto K, Nakagawa S, Ueki S, Morita H, Miyairi I. Eosinophil Extracellular Traps in the Casts of Plastic Bronchitis Associated With Influenza Virus Infection. Chest. 2021;160:854-857.
15. Eljaszewicz A, Ruchti F, Radzikowska U, Globinska A, Boonpiyathad T, Gschwend A, Morita H, Helbling A, Arasi S, Kahlert H, Berek N, Nandy A, Akdis M, Willers C, Moniuszko M, Akdis CA, Sokolowska M. Trained immunity and tolerance in innate lymphoid cells, monocytes, and dendritic cells during allergen-specific immunotherapy. Journal of Allergy Clinical Immunology. 2021;147:1865-1877.
16. Toyoshima S, Sakamoto-Sasaki T, Kurosawa Y, Hayama K, Matsuda A, Watanabe Y, Terui T, Gon Y, Matsumoto K, Okayama Y. miR103a-3p in extracellular vesicles from FcεRI-aggregated human mast cells enhances IL-5 production by group 2 innate lymphoid cells. J Allergy Clin Immunol 2021;147:1878-1891
17. Mishima S, Kashiwakura J, Toyoshima S, Sasaki-Sakamoto T, Sano Y, Nakanishi K, Matsumoto K, Okayama Y. Higher PGD2 production by synovial mast cells from rheumatoid arthritis patients compared with osteoarthritis patients via miR-199a-3p/prostaglandin synthetase 2 axis. Sci Rep 2021;11:5738
18. Eljaszewicz A, Ruchti F, Radzikowska U, Globinska A, Boonpiyathad T, Gschwend A, Morita H, Helbling A, Arasi S, Kahlert H, Berek N, Nandy A, Akdis M, Willers C, Moniuszko M, Akdis CA, Sokolowska M. Trained immunity and tolerance in innate lymphoid cells, monocytes, and dendritic cells during allergen-specific immunotherapy. Journal of Allergy Clinical Immunology. 2021;147:1865-1877.
19. Ito N, Tsukamoto K, Taniguchi K, Takahashi K, Okamoto A, Aoki H, Otera-Takahashi Y, Kitagawa M, Ogata-Kawata H, Morita H, Hata K, Nakabayashi K. Isolation and characterization of fetal nucleated red blood cells from maternal blood as a target for cingle cell sequencing-based non-invasive genetic testing. Reproductive Medicine and Biology. 2021;20:352-360.
20. Yamamoto M, Nagashima S, Yamada Y, Murakoshi T, Shimoyama Y, Takahashi S, Seki H, Kobayashi T, Hara Y, Tadaki H, Ishimura N, Ishihara S, Kinoshita Y, Morita H, Ohya Y, Saito H, Matsumoto K, Nomura I. Comparison of Nonesophageal Eosinophilic Gastrointestinal Disorders with Eosinophilic Esophagitis: A Nationwide Survey. Journal of Allery and Clinical Immunology in Practice 2021;9:3339-3349.
21. Okuzumi S, Miyata J, Kabata H, Mochimaru T, Kagawa S, Masaki K, Irie M, Morita H, Fukunaga K. TLR7 Agonist Suppresses ILC2-mediated Inflammation via IL-17-producing Interstitial Macrophages. American Journal of Respiratory Cell and Molecular Biology. 2021;65:309-318.
22. Yang L, Sato M, Saito-Abe M, Irahara M, Nishizato M, Sasaki H, Konishi M, Ishitsuka K, Mezawa H, Yamamoto-Hanada K, Matsumoto K, Ohya Y; Japan Environment and Children's Study (JECS) Group. Hypertensive disorders of pregnancy and risk of allergic conditions in children: Findings from the Japan Environment and Children's study (JECS). World Allergy Organ Journal. 2021 11;14:100581.
23. Yoshida T, Matsumoto K, Miyado M, Miyashiro Y, Sago H, Horikawa R, Fukami M. Quantification of androgens and their precursors in full-term human placenta. European Journal of Endocrinology 2021 ;185:K7-K11
24. Kawada M, Yokoi H, Kimura T, Matsumoto Y, Sakurai H, Matsumoto K, Fujiwara M, Saito K. Involvement of galanin and galanin receptor 2 in a mouse model of allergic rhinitis. Allergology Interational. 2022;71:83-93
25. Sahiner UM, Layhadi JA, Golebski K, Istvan Komlosi Z, Peng Y, Sekerel B, Durham SR, Brough H, Morita H, Akdis M, Turner P, Nadeau K, Spits H, Akdis C, Shamji MH. Innate lymphoid cells: The missing part of a puzzle in food allergy. Allergy 2021;76:2002-2016

2020

1. Emi-Sugie, M, Shoda T, Futamura K, Takeda T, Ainai A, Hasegawa H, Saito H, Matsumoto K, Matsuda A, Robust production of IL-33 and TSLP by lung endothelial cells in response to low-dose dsRNA. Journal of Allergy and Clinical Immunology. 2020;146:1449-1452
2. Inoue T, Murakami S, Matsumoto K, Matsuda A, Functional benefits of corticosteroid and IVIG combination therapy in a coronary artery endothelial cell model of Kawasaki disease. Pediatric. Rheumtology. 2020;18:76
3. Unno H, Arae K, Matsuda A, Ikutani M, Tamari M,Motomura K, Toyama S, Suto H, Okumura K, Matsuda A, Morita H, Saito H, Matsumoto K, Nakae S. Critical role of IL-33, but not IL-25 or TSLP, in silica crystal-mediated exacerbation of allergic airway eosinophilia. Biochemical and Biophysical Research Communications.2020;533:493-500
4. Hara M, Morimoto N, Suzuki N, Tsuchihashi N, Komori M, Yoshihama K, Fujii K, Yamaguchi S, Tsunoda M, Tomisato S, Takahashi N, Oyake K, Okuba Y, Fujieda M, Matsumoto K. Transcriptome analysis reveals two distinct endotypes and putative immune pathways in tonsils from children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. Allergy. 2021;76:359-363
5. Fujiwara S, Nakamura H.Chronic active Epstein-Barr virus infection: is it immunodeficiency, malignancy, or both? Cancers (Basel). 2020; 12: 3202.
6. Matsumoto K, Iikura K, Morita H, Saito H. Barrier dysfunction in the atopic march-how does atopic dermatitis lead to asthma in children? Journal of Allergy and Clinical Immunology. 2020;145:1551-1553.
7. Matsumoto K, Saito H. Does asthma affect morbidity or severity of Covid-19? Journal of Allergy and Clinical Immunology. 2020;146:55-57
8. Emi-Sugie M, Saito H, Matsumoto K. Cultured human mast cells release various chemokines after stimulation with IL-33. Allergology International. 2021;70:386-388
9. Fujiwara S, Nakamura H. Animal models for gammaherpesvirus infections: recent development in the analysis of virus-induced pathogenesis. Pathogens. 2020; 9:116
10. Kobari S, Kusakabe T, Momota M, Shibahara T, Hayashi T, Ozasa K, Morita H, Matsumoto K, Saito H, Ito S, Kuroda E, Ishii KJ. IL-33 is Essential for Adjuvant Effect of Hydroxypropyl-β-Cyclodexrin on the Protective Intranasal Influenza Vaccination. Frontiers in Immunology. 2020;11:360
11. Ohno T, Nakamura T, Nakae S, Morita H, Matsumoto K, Saito H, Takeda K, Okumura K, Azuma T. TSLP is a negative regulator of RANKL-induced osteoclastogenesis. Biochemical and Biophysical Research Communications. 2020 ;530:508-512
12. Kimura N, Nomura Y, Aomatsu A, Matsuda A, Imamura Y, Taniguchi Y, Hori D, Morishita Y, Fujita H, Yuri K, Matsumoto K, and Yamaguchi A, Transcatheter aortic valve replacement suppresses the immune response associated with surgical aortic valve replacement. American Journal of Cardiology. 2020;128:35-44
13. Sato M, Yamamoto-Hanada K, Tada H, Irahara M, Saito-Abe M, Matsumoto K, Pak K, Kido H, Ohya Y. Diagnostic performance of IgE avidity for hen's egg allergy in young infants. Journal of Allergy and Clinical Immunology in Practice.2020;8:2417-2420
14. Iwata W, Unoki-Kubota H, Kato H, Shimizu A, Matsumoto M, Imasawa T, Igarashi A, Matsumoto K, Noda T, Terauchi Y, Nangaku M, Kasuga M, Kaburagi Y. Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure. PLoS One. 2020;15:e0229397.
15. Maeda M, Imai T, Ishikawa R, Nakamura T, Kamiya T, Kimura T, Fujita S, Akashi K, Tada H, Morita H, Matsumoto K, Katsunuma T. Effect of oral immunotherapy in children with milk allergy: the ORIMA study. Allergology International. 2021;70:223-228
16. Yonese I, Sakashita C, Imadome KI, Kobayashi T, Yamamoto M, Sawada A, Ito Y, Fukuhara N, Hirose A, Takeda Y, Makita M, Endo T, Kimura SI, Ishimura M, Miura O, Ohga S, Kimura H, Fujiwara S, Arai A. Nationwide survey of systemic chronic active EBV infection in Japan in accordance with the new WHO classification. Blood Advances. 2020;4:2918-2926.
17. Fujishima H, Okada N, Matsumoto K, Shimizu E, Fukuda S, Tomita M. Conjunctival injection reduction in patients with atopic keratoconjunctivitis due to synergic effect of bovine enteric-coated lactoferrin in 0.1% tacrolimus ophthalmic suspension. Journal of Clinical Medicine. 2020;9:3093
18. Radzikowska U, Ding M, Tan G, Zhakparov D, Peng P, Wawrzyniak P, Wang S, Li S, Morita H, Altunbulakli C, Reiger M, Neumann AU, Lunjani N, Traidl-Hoffmann C, Nadeau K, O'Mahony L, Akdis CA, Sokolowska M. Distribution of ACE2, CD147, CD26 and other SARS-CoV-2 associated molecules in tissue and immune cells in health and in asthma, COPD, obesity, hypertension and COVID-19 risk factors. Allergy. 2020;75:2829-2845.
19. Adachi T, Kainuma K, Asano K, Amagai M, Arai H, Ishii KJ, Ito K, Uchio E, Ebisawa M, Okano M, Kabashima K, Kondo K, Konno S, Saeki H, Sonobe M, Nagao M, Hizawa N, Fukushima A, Fujieda S, Matsumoto K, Morita H, Yamamoto K, Yoshimoto A, Tamari M. Strategic Outlook toward 2030: Japan's research for allergy and immunology-Secondary publication. Allergology International. 2020;69:561-570.
20. Fukuie T, Nishiura H, Miyaji Y, Matsumoto K, Ohya Y, Saito H. Effect of specific IgE on eliciting dose in children with cow's milk allergy. Journal of Allergy and Clinical Immunology in Practice. 202;8:3660-3662
21. Sato M, Yamamoto-Hanada K, Tada H, Irahara M, Saito-Abe M, Matsumoto K, Pak K, Kido H, Ohya Y. Diagnostic performance of IgE avidity for hen's egg allergy in young infants. Journal of Allergy and Clinical Immunology in Practice. 2020;8:2417-2420
22. Sokolowska M, Lukasik Z, Agache I, Akdis CA, Akdis, D, Akdis M, Barcik W, Brough H, Eiwegger T, Eliaszewicz A, Eyerich S, Feleszko W, Gomez Casado C, Hoffmann-Sommergruber K, Janda J, Jimenez-Saiz R, Jutel M, Knol E, Kortekaas Krohn I, Kothari A, Makowska J, Moniuszko M, Morita H, O'Mahony L, Nadeau K, Ozdemir C, Pali-Scholl I, Palomares O, Papaleo F, Prunicki M, Schmidt-Wever CB, Sediva A, Schwarze J, Shamji MH, Tramper-Stranders G, van de Veen W, Untersmayr E. Immunology of COVID-19: mechanisms, clinical outcome, diagnostics and perspectives - a report of the European Academy of Allergy and Clinical Immunology (EAACI). Allergy. 2020;75:2445-2476.

2019

1. Morita H, Tamari M, Fujiwara M, Motomura K, Koezuka Y, Ichien G, Matsumoto K, Ishizaka K, Saito H. IgE-class-specific immunosuppression in offspring by administration of anti-IgE to pregnant mice. Journal of Allergy and Clinical Immunology. 2019;143:1261-1264.
2. Morita H, Kubo T, Rückert B, Ravindran A, Soyka M, Rinaldi A, Sugita K, Wawrzyniak M, Wawrzyniak P, Motomura K, Tamari M, Orimo K, Okada N, Arae K, Saito K, Altunbulakli C, Castro-Giner F, Tan G, Neumann A, Sudo K, O'Mahony L, Honda K, Nakae S, Saito H, Mjösberg J, Nilsson G, Matsumoto K, Akdis M, Akdis CA. Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid. Journal of Allergy and Clinical Immunology. 2019;143:2190-2201.
3. Kashiwakura J, Ando T, Karasuyama H, Kubo K, Matsumoto K, Matsuda T, Kawakami T. The basophil-IL-4-mast cell axis is required for food allergy. Allergy 2019;74:1992-1996
4. Tanase-Nakao K, Mizuno K, Hayashi Y, Kojima Y, Hara M, Matsumoto K, Matsubara Y, Igarashi M, Miyado M, Fukami M. Dihydrotestosterone induces minor transcriptional alterations in genital skin fibroblasts of children with and without androgen insensitivity. Endocrine Journal 2019;66:387-393
5. Sugita K, Altunbulakli C, Morita H, Sugita A, Kubo T, Kimura R, Goto H, Yamamoto O, Rückert B, Akdis M, Akdis CA. Human type 2 innate lymphoid cells disrupt skin keratinocyte tight junction barrier by IL-13. Allergy. 2019;74:2534-2537
6. Rinaldi AO, Morita H, Wawrzyniak P, Dreher A, Grant S, Svedenhag P, Akdis CA. Direct assessment of skin epithelial barrier by electrical impedance spectroscopy. Allergy. 2019;74:1934-1944
7. Li S, Morita H, Sokolowska M, Tan G, Boonpiyathad T, Opitz L, Orimo K, Archer S, Jansen K, Tang M, Purcell D, Plebanski M, Akdis CA. Gene expression of signature of circulating human type 1, 2 and 3 innate lymphoid cells. Journal of Allergy and Clinical Immunology. 2019;143:2321-2325.
8. Boonpiyathad T, Sokolowska M, Morita H, Rückert B, Kast JI, Wawrzyniak M, Sangasapaviliya A, Pradubpongsa P, Fuengthong R, Thantiworasit P, Sirivichayakul S, Kwok WW, Ruxrungtham K, Akdis M, Akdis CA. Der p 1-specific regulatory T cell response during house dust mite allergen immunotherapy. Allergy. 2019;7:976-985.
9. Nakashima A, Cheng SB, Kusabiraki T, Motomura K, Aoki A, Ushijima A, Ono Y, Tsuda S, Shima T, Yoshino O, Sago H, Matsumoto K, Sharma S, Saito S. Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts. Scientific Reports. 2019;9:11466.

2018

1. Matsumoto K, Mori R, Miyazaki C, Ohya Y, Saito H. Are both early egg introduction and eczema treatment necessary for primary prevention of egg allergy? Journal of Allergy and Immunology 2018;141:1997-2001
2. Okada N, Sasaki A, Saito J, Mitani Y, Yachie A, Takahashi H, Matsubara S, Tenkumo C, Tanaka H, Hata T, Motomura K, Nagasawa J, Wada Y, Sako M, Yamaguchi K, Matsumoto K, Nakamura H, Sago H, Mizuta K. The Japanese experience and pharmacokinetics of antenatal maternal high-dose immunoglobulin treatment as a prophylaxis for neonatal hemochromatosis in siblings. Journal of Maternal, Fetal and Neonatal Medicine. 2018;33:142-148
3. Emi-Sugie M, Toyama S, Matsuda A, Saito H, Matsumoto K. IL-33 induces functional CCR7 expression in human mast cells. Journal of Allergy and Clinical Immunology. 2018;142:1341-1344
4. Matsuda A. Editorial: Platelets: Pivotal player in primary sensitization to allergen? American Journal of Respiratory Cell and Molecular Biology 2018;59:7-8.
5. Saito H. Legend of Allergy & Immunology: KImishie Ishizaka. Allergy 2019;74:12-13.
6. Saito M, Yamamoto-Hanada K, Pak K, Ayabe T, Mezawa H, Ishizuka K, Konishi M, Yang L, Matsumoto K, Saito H, Ohya Y. the Japan Environment and Children's Study (JECS) Group. Having small for gestational age infants were associated with maternal allergic features in the JECS birth cohort. Allergy 2018;73:1908-1911
7. Higaki S, Muramatsu M, Matsuda A, Matsumoto K, Satoh J, Michikawa M, Niida S. Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models. PLoS One 2018 8;13:e0196929.
8. Yamamoto-Hanada K, Ishitsuka K, Pak K, Saito M, Ayabe T, Mezawa H, Konishi M, Yang L, Matsumoto K, Saito H, Ohya Y. Japan Environment and Children's Study (JECS) Group. Allergy and mental health among pregnant women in the Japan Environment and Children's Study. Journal of Allergy and Clinical Immunology in Practice 2018;6:1421-1424.e2
9. Matsumoto Y, Yokoi H, Kimura T, Matsumoto Y, Kawada M, Arae K, Nakae S, Ikeda T, Matsumoto K, Sakurai H, Saito K. Gastrin-releasing peptide (GRP) is involved in the establishment of allergic rhinitis in mice. Laryngoscope 2018;128:E377-E384
10. Takamori A, Nambu A, Sato K, Yamaguchi S, Matsuda K, Numata T, Sugawara T, Yoshizaki T, Arae K, Morita H, Matsumoto K, Sudo K, Okumura K, Kitaura J, Matsuda H, Nakae S. IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity. Scientific Report. 2018;8:6639
11. Ohki K, Kiyokawa N, Saito Y, Hirabayashi S, Nakabayashi K, Ichikawa H, Momozawa Y, Okamura K, Yoshimi A, Ogata-Kawata H, Sakamoto H, Kato M, Fukushima K, Hasegawa D, Fukushima H, Imai M, Kajiwara R, Koike T, Komori I, Matsui A, Mori M, Moriwaki K, Noguchi Y, Park MJ, Ueda T, Yamamoto S, Matsuda K, Yoshida T, Matsumoto K, Hata K, Kubo M, Matsubara Y, Takahashi H, Fukushima T, Hayashi Y, Koh K, Manabe A, Ohara A. Clinical and molecular characteristics of MEF2D fusion-positive precursor B-cell acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion. Haematologica. 2019;104:128-137
12. Arae K, Morita H, Unno H, Motomura K,Toyama S, Okada N, Ohno T, Tamari M, Orimo K, Mishima Y, Suto H, Okumura K, Sudo K, Miyazawa H, Taguchi H, Saito H, Matsumoto K, Nakae S. Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1β production by DCs. Scientific Reports. 2018;8:11721
13. Yang L, Narita M, Yamamoto-Hanada K, Sakamoto N, Saito H, Ohya Y. Phenotypes of childhood wheeze in Japanese children: A group-based trajectory analysis. Pediatric Allergy and Immunology 2018;29:606-611.
14. Hiraishi Y, Nambu A, Yamaguchi S, Shimura E, Takamori A, Narushima S, Nakanishi W, Asada Y, Yoshizaki T, Numata T, Suzukawa M, Yamauchi Y, Matsuda A, Arae K, Morita H, Hoshino T, Suto H, Okumura K, Matsumoto K, Saito H, Sudo K, Iikura M, Nagase T, Nakae S. IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation. Scientific Reports. 2018; 8: 18502.
15. Yamaguchi S, Nambu A, Numata T, Yoshizaki T, Narushima S, Shimura E, Hiraishi Y, Arae K, Morita H, Matsumoto K, Hisatome I, Sudo K, Nakae S. The roles of IL-17C in T cell-dependent and -independent inflammatory diseases. Scientific Reports. 2018; 8: 15750.

2017

1. Toyama S, Okada N, Matsuda A, Morita H, Saito H, Fujisawa T, Nakae S, Karasuyama H, Matsumoto K. Human eosinophils constitutively express a unique serine protease, PRSS33. Allergology International 2017;66:463-471
2. Motomura K, Okada N, Morita H, Hara M, Tamari M, Orimo K, Matsuda G, Imadome K, Matuda A, Nagamatsu T, Fujieda M, Sago H, Saito H, Matsumoto K. A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro. PLoS One. 2017;12:e0177994.
3. Morita H, Suzuki H, Orihara K, Motomura K,Matsuda A, Ohya Y, Saito H, Nomura I, Matsumoto K. Food protein-induced enterocolitis syndromes with and without bloody stool have distinct clinicopathological features. Journal of Allergy and Clinical Immunology. 2017;140:1718-1721
4. Shoda T, Matsuda A, Nomura I, Okada N, Orihara K, Mikami H, Ishimura N, Ishihara S, Matsumoto K, Kinoshita Y. Eosinophilic esophagitis versus proton pump inhibitor-responsive esophageal eosinophilia: Transcriptome analysis. Journal of Allergy and Clinical Immunology. 2017;139:2010-2013
5. Motomura K, Ganchimeg T, Nagata C, Ota E, Vogel J, Betrán AP, Torloni MR, Jayaratne K, Jwa S-K, Mittal S, Recidoro ZD, Matsumoto K, Fujieda F, Idi N, Yunis K, Qureshi Z, Paulo Souza J, Mori R. Incidence and outcomes of uterine rupture among women with prior caesarean section: WHO Multicountry Survey on Maternal and Newborn Health. Sci. Rep. 2017:7, 44093
6. Orihara K, Odemuyiwa SO, Stefura WP, Ilarraza R, HayGlass KT, Moqbel R. Neurotransmitter signalling via NMDA receptors leads to decreased T helper type 1-like and enhanced T helper type 2-like immune balance in humans. Immunology. 2018;153:368-379
7. Tamari M, Orimo K, Motomura K, Arae K, Matsuda A, Nakae S, Saito H, Morita H, Matsumoto K. The optimal age for epicutaneous sensitization following tape-stripping in BALB/c mice. Allergol Int. 2018;67:380-387
8. Kimura N, Futamura K, Arakawa M, Okada N, Emrich F, Okamura H, Sato T, Shudo , Koyano TK, Yamaguchi A, Adachi H, Matsuda A, Kawahito K, Matsumoto K, Fischbein MP. Gene expression profiling of acute type A aortic dissection combined with in vitro assessment. European Journal of Cardio-Thoracic Surgery. 2017;52:810-817
9. Okada N, Nakayama T, Asaka D, Inoue N, Tsurumoto T, Takaishi S, Otori N, Kojima H, Matsuda A, Oboki, K Saito H, Matsumoto K, Yoshikawa M*. Distinct gene expression profiles and regulation networks of nasal polyps in eosinophilic and non-eosinophilic chronic rhinosinusitis. International Forum of Allergy & Rhinology. 2018;8:592-604
10. Shinohara M, Matsumoto K. Fetal tobacco smoke exposure in the third trimester of pregnancy is associated with atopic eczema/dermatitis syndrome in infancy. Pediatric Allergy, Immunology, and Pulmonology 2017;30:155-162
11. Li S, Morita H, Rückert B, Boonpiyathad T, Neumann A, Akdis CA. Type 3 innate lymphoid cells induce proliferation of CD94+ NK cells. Journal of Allergy Clinical Immunology 2017;140:1156-1159
12. Sakaki M, Ebihara Y, Okamura K, Nakabayashi K, Igarashi A, Matsumoto K, Hata K, Kobayashi Y, Maehara K. Potential Roles of DNA Methylation in the Initiation and Establishment of Replicative Senescence Revealed by Array-Based Methylome and Transcriptome Analyses. PLoS One. 2017;12:e0171431
13. Ito Y, Inoue A, Seers T, Hato Y, Igarashi A, Toyama T, Taganov K, Boldin M, Asahara H. Identification of targets of tumor suppressor microRNA-34a using a reporter library system. PNAS 2017;114:3927-3932
14. Nowak-Węgrzyn A, Chehade M, Groetch ME, Spergel JM, Wood RA, Allen K, Atkins D, Bahna S, Barad AV, Berin C, Whitehorn TB, Burks AW, Caubet JC, Cianferoni A, Conte M, Davis C, Fiocchi A, Grimshaw K, Gupta R, Hofmeister B, Hwang JB, Katz Y, Konstantinou GN, Leonard SA, Lightdale J, McGhee S, Mehr S, Sopo SM, Monti G, Muraro A, Noel SK, Nomura I, Noone S, Sampson HA, Schultz F, Sicherer SH, Thompson CC, Turner PJ, Venter C, Westcott-Chavez AA, Greenhawt M. International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: Executive summary-Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology. Journal of Allergy and Clinical Immunology. 2017;139:1111-1126
15. Masamichi Sato, Tetsuo Shoda, Hirotaka Shimizu, Kanami Orihara, Kyoko Futamura, Akio Matsuda, Yoshiyuki Yamada, Rie Irie, Takako Yoshioka, , Toshiaki Shimizu, Yukihiro Ohya, Ichiro Nomura, Kenji Matsumoto, Katsuhiro Arai, Gene expression patterns in distinct endoscopic findings for eosinophilic gastritis in children. Journal of Allergy and Clinical Immunology in Practice 2017;5:1639-1649
16. Kimura Y, Mori D, Imada T, Izuta Y, Shibuya M, Sakaguchi H, Oonishi E, Okada N, Matsumoto K, Tsubota K. Restoration of tear secretion in a murine dry eye model by oral administration of palmitoleic acid. Nutrients. 2017; 9:364.
17. Yamamoto-Hanada K, Yang L, Ishitsuka K, Ayabe T, Mezawa H, Konishi M, Shoda T, Matsumoto K, Saito H, Ohya Y. Allergy characteristics of Japanese parents in the Japan Environment and Children's Study: a nationwide birth cohort study. World Allergy Organization Journal 2017;10:24
18. Sugita K, Steer CA, Martinez-Gonzalez I, Altunbulakli C, Morita H, Castro-Giner F, Kubo T, Wawrzyniak P, Rückert B, Sudo K, Nakae S, Matsumoto K, O'Mahony L, Akdis M, Takei F, Akdis CA. Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients. Journal of Allergy and Clinical Immunology.2018;141:300-310
19. Sato M, Shoda T, Shimizu H, Orihara K, Futamura K,Matsuda A, Yamada Y, Irie R, Yoshioka T, Shimizu T, Ohya Y, Nomura I, Matsumoto K, Arai K. Gene Expression Patterns in Distinct Endoscopic Findings for Eosinophilic Gastritis in Children. Journal of Allergy and Clinical Immunology: In Practice. 2017;5:1639-1649
20. Mitsui M, Shoda T, Natsume O, Nomura I, Narita M, Fukuda A, Sakamoto S, Kasahara M, Ohya Y. Factors Associated with Development of Food Allergy in Young Children after Liver Transplantation: A Retrospective Analysis of 10 Years' Experience. Journal of Allergy and Clinical Immunology: In Practice 2017;5:1698-1706
21. Ando T, Kashiwakura J, Itoh-Nagato N, Yamashita H, Baba M, Kawakami Y, Tsai SH, Inagaki N, Takeda K, Iwata T, Shimojo N, Fujisawa T, Nagao M, Matsumoto K, Kawakami Y, Kawakami T. Histamine-releasing factor enhances food allergy. Journal of Clinical Investigation 2017;127:4541-4553
22. Mori T, Sakai Y, Kayano M, Matsuda A, Oboki K, Matsumoto K, Harada A, Niida S, Watanabe K. MicroRNA transcriptome analysis on hypertrophy of the ligamentum flavum from patients with lumbar spinal stenosis. Spine Surgery and Related Research 2017;1:211-217
23. Demenais F, Matsumoto K, et al. Multi-ancestry genome-wide association study identifies new asthma susceptibility loci that co-localize with immune cell enhancer histone marks. Nature Genetetics 2018;50:42-53.
24. Ishihara, S., T. Shoda, N. Ishimura, S. Ohta, J. Ono, Y. Azuma, E. Okimoto, K. Izuhara, I. Nomura, K. Matsumoto and Y. Kinoshita. "Serum Biomarkers for the Diagnosis of Eosinophilic Esophagitis and Eosinophilic Gastroenteritis. Internal medicine　2017;56:2819-2825
25. Yamaoka M, Akiyama M, Oyama W, Tachimoto H, Matsumoto K. Acute lymphoblastic leukemia with hypereosinophilia in a 3-year-old boy. Pediatrics International 2018;60:88-90
26. Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, Shimura E, Arae K, Asada Y, Motomura K, Kaneko M, Abe T, Matsuda A, Iwakura Y, Okumura K, Saito H, Matsumoto K, Sudo K, Nakae S. IL-25 enhances Th17 cell-mediated contact dermatitis by promoting IL-1b production by dermal dendritic cells. Journal of Allergy and Immunology 2018;142:1500-1509
27. Trabanelli S, Chevalier MF, Martinez-Usatorre A, Gomez-Cadena A, Salome B, Lecciso M, Salvestrini V, Verdeil G, Racle J, Papayannidis C, Morita H, Pizzitola I, Grandclement C, Bohner P, Bruni E, Girotra M, Pallavi R, Falvo P, Leibundgut EO, Baerlocher GM, Carlo-Stella C, Taurino D, Santoro A, Spinelli O, Rambaldi A, Giarin E, Basso G, Tresoldi C, Ciceri F, Gfeller D, Akdis CA, Mazzarella L, Minucci S, Pelicci PG, Marcenaro E, McKenzie ANJ, Vanhecke D, Coukos G, Mavillio D, Curti A, Derre L, Jandus C. Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis. Nature Communication. 2017;8:593.